Browse our Research Articles

Page 354 of 1,393
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors

    Alba Timón-Gómez, Alexandra L Scharr ... Andy J Chang
    An atypical configuration of mitochondrial electron transport chain proteins may underlie the exquisite sensitivity of the carotid body to small decreases in oxygen availability.
    1. Microbiology and Infectious Disease

    Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases

    Julia Takuno Hespanhol, Daniel Enrique Sanchez-Limache ... Ethel Bayer-Santos
    Salmonella antibacterial effectors act on Y-shaped DNA substrates resembling replication forks or transcription bubbles and lead to DNA double-strand breaks.
    1. Medicine

    Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: A retrospective cohort study

    Anne Hebert, Annet Simons ... Caspar I van der Made
    Systematic assessment of de novo variants in patients with sporadic inborn errors of immunity led to the identification of promising candidate variants in known and novel immune genes, supporting its implementation in the routine diagnostic evaluation of these patients.
    1. Neuroscience

    An inhibitory circuit from central amygdala to zona incerta drives pain-related behaviors in mice

    Sudhuman Singh, Torri D Wilson ... Yarimar Carrasquillo
    Inhibition of the zona incerta by central amygdala neurons expressing PKCδ contributes to injury-induced peripheral hypersensitivity in a mouse model of neuropathic pain.
    1. Microbiology and Infectious Disease

    Ferric reductase-related proteins mediate fungal heme acquisition

    Udita Roy, Shir Yaish ... Daniel Kornitzer
    A new class of plasma membrane proteins involved in heme-iron utilization provides a molecular link between the extracellular and intracellular parts of the fungal heme acquisition pathway, and reveals the evolutionary origin of this pathway.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans

    Jun Kim, David S Jimenez ... Sevinc Ercan
    Loading and linear translocation of condensin dosage compensation along the X-chromosomes create the loop-anchored topologically associating domains detected by Hi-C.
    1. Computational and Systems Biology
    2. Neuroscience

    The interpretation of computational model parameters depends on the context

    Maria Katharina Eckstein, Sarah L Master ... Anne GE Collins
    Context factors such as experimental task and model parameterization can significantly impact modeling results, such that across tasks, the same participants show different fitted parameter values, and parameters capture different cognitive processes across tasks.
    1. Neuroscience

    Recalibrating vision-for-action requires years after sight restoration from congenital cataracts

    Irene Senna, Sophia Piller ... Marc O Ernst
    Late cataract-treated individuals learn to recalibrate vision for action in the months to years after sight restoration surgery, demonstrating that this ability can develop even in the absence of early pattern vision.
    1. Neuroscience

    Vocalization categorization behavior explained by a feature-based auditory categorization model

    Manaswini Kar, Marianny Pernia ... Srivatsun Sadagopan
    A theoretical model that uses maximally informative spectrotemporal features to classify vocalizations, trained solely on natural guinea pig vocalizations, predicts guinea pig behavioral performance in classifying natural as well as spectrotemporally manipulated vocalizations.
    1. Neuroscience

    Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function

    Rohit Singh Rawat, Aksheev Bhambri ... Arpita Konar
    Hypothalamic TTR as a novel molecular player of stress-induced long-term impact on behavior.