Browse our Research Articles

Page 40 of 1,434
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

    Laura Sophie Kremer, Guanbin Gao ... Nils-Göran Larsson
    Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates

    Samantha J Ziegler, Brandon C Knott ... Yannick J Bomble
    Understanding the dynamics of AdhE enzymes is essential to be able to control the metabolic and energy fluxes in microorganisms used to produce biofuels and biochemicals.
    1. Neuroscience

    Neurons throughout the brain embed robust signatures of their anatomical location into spike trains

    Gemechu Bekele Tolossa, Aidan M Schneider ... Keith B Hengen
    Machine learning analysis reveals that individual neurons throughout the brain embed information about their anatomical location in their spike trains, a feature that generalizes across animals, experimental conditions, and laboratories.
    1. Cell Biology

    Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation

    Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz
    Focal adhesion derived p130Cas condensates regulate translation in an adhesion strength dependent manner.
    1. Cancer Biology
    2. Medicine

    Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan
    Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

    Cheryll M Sia, Rebecca L Ambrose ... Danielle J Ingle
    The most comprehensive analysis of Salmonella Dublin to date uncovers distinct genotypic adaptations, antimicrobial resistance patterns, and virulence strategies that influence epidemiological success.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

    Lan Yao, Wanwan Zhang ... Kuntong Jia
    MYL3 is identified as a novel receptor enabling nervous necrosis virus (NNV) entry via macropinocytosis, revealing a therapeutic target for combating NNV outbreaks in aquaculture.
    1. Neuroscience

    Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output

    Nirvik Sinha, Sharon Israely ... Yifat Prut
    Reversible cerebellar disruption in non-human primates reveals an acute muscle torque deficit and an adaptive slowing strategy to manage limb dynamics, underscoring distinct primary, and compensatory mechanisms underlying motor impairment.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

    Jodie Chandler, M Elise Bullock ... Andrew J Yates
    Memory CD4 T cells within tissues are highly dynamic, and their continuous replacement may erode immunity to previous infections.
    1. Neuroscience

    Investigating working memory updating processes of the human subcortex using 7T MRI

    Anne C Trutti, Zsuzsika Sjoerds ... Birte U Forstmann
    Neuroimaging evidence enhances understanding of the subcortex’s role in the neural mechanisms of working memory updating, providing new insights into midbrain function.