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CapZ controls actin filament density around immature early endosomes via its C-terminal domain to facilitate the homotypic fusion of the endocytic vesicles, and it functions as a scaffold protein via its N-terminal domain to recruit RAB5 effectors to early endosomes.

Unidirectional crosstalk occurs between signaling competent EGFR dimers activating RON within heteromeric complexes at the plasma membrane.

A novel process by which counter-regulatory glucagon release is regulated in both mouse and human.

In vivo calcium imaging reveals that prior to visual experience, inhibitory spontaneous activity in the developing visual cortex is highly modular and participates in large-scale correlated networks that are co-aligned to excitatory activity.

Cell-free DNA methylation markers allow monitoring of immune and inflammatory cell turnover.

Single-molecule FRET measurements and protein crosslinking reveal the compact structure of quiescent STIM1 and the conformational rearrangements that enable it to activate store-operated calcium entry.

Pulse generation is an emergent property of the arcuate kisspeptin network that is regulated throughout the ovarian cycle via coordinated changes in neuronal communication and basal activation.

Lactate is preferred to glucose as an energy substrate and exacerbates spiking activity in most neuron types of juvenile somatosensory cortex by closing ATP-sensitive potassium channels.

A large repertoire of nanobodies that target discrete regions of SARS-CoV-2 spike shows effective neutralization against variants of concern with many pairwise combinations resistant to escape and demonstrating synergistic neutralization activities.

A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.