Browse our Research Articles

Page 623 of 1,391
    1. Developmental Biology
    2. Neuroscience

    Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

    J Roman Arguello, Liliane Abuin ... Richard Benton
    Targeted expression of molecular probes for gene expression and chromatin accessibility in subpopulations of neurons in the Drosophila olfactory system identifies genes required for their development and function.
    1. Immunology and Inflammation
    2. Neuroscience

    Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

    Sina C Rosenkranz, Artem A Shaposhnykov ... Manuel A Friese
    Inducing neuronal mitochondrial activity during central nervous system inflammation counteracts inflammation-induced neuronal electron transport chain deficiency and calcium toxicity, thereby protecting against neuronal loss in a multiple sclerosis mouse model.
    1. Genetics and Genomics

    Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

    Swati Gaikwad, Fardin Ghobakhlou ... Alan G Hinnebusch
    A mutant impaired for ribosome recycling exhibits translational reprogramming wherein strong mRNAs outcompete weak mRNAs, also observed when preinitiation complexes are diminished by eIF2α phosphorylation or 40S ribosomal subunit depletion.
    1. Neuroscience

    Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry

    Gregory G Grecco, Briana E Mork ... Brady K Atwood
    A novel, translational mouse model of prenatal methadone exposure was developed and a longitudinal assessment of offspring revealed impairments in physical, behavioral, and neuronal development.
    1. Developmental Biology

    A gradient of Wnt activity positions the neurosensory domains of the inner ear

    Magdalena Żak, Nicolas Daudet
    Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
    1. Chromosomes and Gene Expression

    Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

    Nina Kirstein, Alexander Buschle ... Aloys Schepers
    Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    PomX, a ParA/MinD ATPase activating protein, is a triple regulator of cell division in Myxococcus xanthus

    Dominik Schumacher, Andrea Harms ... Lotte Søgaard-Andersen
    In the PomX/Y/Z cell division regulatory system, PomX is a PomZ ATPase activating protein, a scaffold for PomX/Y/Z complex formation, and important for fission of the PomX/Y/Z complex during division.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Archaeal chromatin ‘slinkies’ are inherently dynamic complexes with deflected DNA wrapping pathways

    Samuel Bowerman, Jeff Wereszczynski, Karolin Luger
    Archaeal histones compact DNA into nucleosome-like particles of varying sizes that contort sporadically and reorient DNA wrapping.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    eIF2B conformation and assembly state regulate the integrated stress response

    Michael Schoof, Morgane Boone ... Peter Walter
    eIF2-P activates the integrated stress response by inducing a conformational change in eIF2B that decreases substrate (eIF2) binding and reduces eIF2B's catalytic activity.
    1. Neuroscience

    Performance in even a simple perceptual task depends on mouse secondary visual areas

    Hannah C Goldbach, Bradley Akitake ... Mark H Histed
    In a simple visual task, that in principle could be performed using information in V1 alone, perturbations of secondary visual areas impair perception.