Browse our Research Articles

Page 624 of 1,390
    1. Structural Biology and Molecular Biophysics

    Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

    Kangcheng Song, Miao Wei ... Lei Chen
    The binding sites of two distinct TRPC5 inhibitors clemizole and HC-070 are revealed by cryo-EM.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi, Satoko Hakeda-Suzuki ... Takashi Suzuki
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Genetics and Genomics

    Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

    Helen M Tauc, Imilce A Rodriguez-Fernandez ... Heinrich Jasper
    Global, multi-angled genetic analyses identified an age-associated loss of stem cell lineage fidelity that was linked to changes in polycomb regulation in the Drosophila intestinal epithelium.
    1. Plant Biology

    Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions

    Manuela Kramer, Melvin Rodriguez-Heredia ... Guy Thomas Hanke
    The regulatory switch from protection to assimilation, which plants use to exploit natural, fluctuating light, involves movement of the enzyme ferredoxin:NADP(H) oxidoreductase between chloroplast membrane complexes.
    1. Developmental Biology
    2. Physics of Living Systems

    From local resynchronization to global pattern recovery in the zebrafish segmentation clock

    Koichiro Uriu, Bo-Kai Liao ... Luis G Morelli
    Theory explains how transport of gene expression vortices by cell advection may cause intermingled defective and normal segments along the body axis during resynchronization experiments in the zebrafish segmentation clock.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland, Tyler WA Bradshaw ... Scott H Soderling
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Neuroscience

    Development of visual motion integration involves coordination of multiple cortical stages

    Augusto A Lempel, Kristina J Nielsen
    The development of complex motion processing in higher-level visual cortex involves functional changes in primary visual cortex, indicating coordinated development in multiple nodes of the visual hierarchy.
    1. Neuroscience
    2. Physics of Living Systems

    Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

    Aditya Raghunandan, Antonio Ladron-de-Guevara ... Douglas H Kelley
    A new tracer infusion method is used to confirm that pulsatile cerebrospinal fluid transport into the brain occurs naturally and is driven by the cardiac cycle, not by tracer injection.
    1. Genetics and Genomics
    2. Neuroscience

    Sequential perturbations to mouse corticogenesis following in utero maternal immune activation

    Cesar P Canales, Myka L Estes ... Alex S Nord
    Mid-gestational exposure to maternal immune activation drives a sequence of transcriptional signatures and developmental pathology in embryonic mouse cortex, culminating in altered lamination and cellular lineage specification.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

    Daniel B Larremore, Bailey K Fosdick ... Yonatan H Grad
    Integrating over multiple forms of statistical uncertainty associated with serological surveys can improve serosurvey design while also enabling that uncertainty to be appropriately propagated through epidemiological models.