Ariana R Andrei, Samantha Debes ... Valentin Dragoi
Focal optogenetic inactivation of cortex induces complex changes in neural responses outside the targeted area that can influence behavioral performance.
Lawrence Lubyayi, Harriet Mpairwe ... Alison M Elliott
In a Ugandan birth cohort, early childhood infection-exposure, notably to malaria, helminths, and diarrhoea, is associated with lower prevalence of atopy and allergy-related diseases in later childhood.
In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).
The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
Mohammed Kaplan, Georges Chreifi ... Grant J Jensen
Electron cryo-tomography reveals that bacteria can form structurally-diverse outer membrane extensions with various protein complexes associated with them.
The crystal structure of human WIPI2 bound to the ATG16L1 WIPI2-interacting region, combined with in vitro reconstitution and cellular autophagy assays, shows how the LC3 lipidation machinery is recruited in autophagy initiation.
David M Garcia, Edgar A Campbell ... Daniel F Jarosz
In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.
Genetic and functional manipulations uncover urocortin-3-expressing neurons in the perifornical area of the hypothalamus as a dedicated circuit component for the expression of infant-directed neglect and aggression in mice.
