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Although the phasic activity of midbrain dopamine neurons is known to represent reward values, these neurons displayed a tonic firing mode to continuously track reward values changing moment-by-moment.

CRISPR/Cas9 based genomic editing for efficient endogenous protein tagging can be achieved by targeting non-coding sequences with two guides.

Ataxin-2 interacts with neuronal mRNA in RNP granules.

The olfactory learning of Caenorhabditis elegans shows that the exonuclease and helicase domains of human Werner syndrome protein (WRN) coordinately regulate the biogenesis of small interfering RNAs to promote neuronal plasticity.

A neuromodulatory circuit bidirectionally regulates the glial capacity to buffer ions and water in response to changes in neuronal excitation in order to balance glial versus neuronal protection.

A single amino acid residue is critical for cardiolipin interaction specificity and nuclear membrane recruitment of a dynamin-related protein.

The transcription factor HAND2 evolved uterine expression during the origins of pregnancy and may be important for maternal-fetal immune signaling and parturition.

A massively parallel analysis of the effects of mutations on amyloid beta nucleation provide the first comprehensive atlas of how mutations alter the formation of amyloid fibrils.

Changes in the prevalence of underweight, total obesity, and severe obesity are largely driven by shifts in the distribution of body mass index.

Mitochondrial fission, associated with fatty acids oxidation, is fundamental for AgRP neuronal activity during negative energy balance and in regulating fasting- and/or ghrelin-induced feeding.