Browse our Research Articles

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    1. Ecology

    Group size and composition influence collective movement in a highly social terrestrial bird

    Danai Papageorgiou, Damien Roger Farine
    High-resolution GPS data revealed a quadratic relationship between group size and movement, with vulturine guineafowl groups of intermediate size exhibiting the largest home-range size and greater variation in site use.
    1. Cancer Biology

    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

    Keerthana Gnanapradeepan, Julia I-Ju Leu ... Maureen E Murphy
    Enhanced metabolic efficiency associated with the tumor-predisposing African-centric p53 variant.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

    Bhavatharini Kasinathan, Serafin U Colmenares III ... Harmit S Malik
    Heterochromatic sequences evolve rapidly, as do ZAD-ZNF genes-encoding proteins involved in heterochromatin functions, explaining why evolutionarily dynamic ZAD-ZNF genes are more likely to be essential in Drosophila.
    1. Neuroscience

    Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

    Sthitapranjya Pati, Kamal Saba ... Vidita A Vaidya
    Enhanced Gq-signaling-mediated activation of forebrain excitatory neurons in postnatal life programs enhanced anxiety-, despair- and schizophrenia-like behavior, recapitulating key aspects of the behavioral consequences of early life adversity.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution of multicellularity by collective integration of spatial information

    Enrico Sandro Colizzi, Renske MA Vroomans, Roeland MH Merks
    Selection for undifferentiated multicellularity emerges in an evolutionary cell-based model because a collective of cells performs chemotaxis better than single cells in a noisy environment.
    1. Microbiology and Infectious Disease

    A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells

    Brian L Hua, Florine EM Scholte ... Éric Bergeron
    Tick-derived sequence variation in the fusion glycoprotein of Crimean-Congo hemorrhagic fever virus (CCHFV) drastically impairs infection of mammalian cells, suggesting that certain CCHFV strains undergo purifying selection in mammalian hosts.
    1. Cell Biology

    Functional exploration of heterotrimeric kinesin-II in IFT and ciliary length control in Chlamydomonas

    Shufen Li, Kirsty Y Wan ... Junmin Pan
    Experimental and modelling analyses suggest a non-linear scaling relationship between IFT velocity and ciliary length that can be accounted for by limitation of the motors.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A natural variant of the essential host gene MMS21 restricts the parasitic 2-micron plasmid in Saccharomyces cerevisiae

    Michelle Hays, Janet M Young ... Harmit S Malik
    A novel assay to measure 2-micron stability together with a survey of natural variation among Saccharomyces cerevisiae strains reveals novel means by which yeasts can combat the parasitic 2-micron plasmids.
    1. Structural Biology and Molecular Biophysics

    Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

    Xue Fei, Tristan A Bell ... Robert T Sauer
    Cryo-EM structures of the AAA+ ClpXP protease bound to an ssrA degron reveal the mechanism of substrate recognition and show how the machine transitions from recognition to translocation and unfolding.
    1. Medicine

    Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver

    Harriet Hunter, Dana de Gracia Hahn ... Jake P Mann
    Animal studies of fatty liver disease over-estimate the benefit of drugs due to publication bias and are confounded by off-target weight loss, illustrating the challenge of successful translational across species.