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The INM protein LAP1B, an activator of Torsin ATPases, is a chromatin-binding factor that erroneously persists on mitotic chromatin if Torsin functionality is compromised, inducing chromosome segregation defects and binucleation.

Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.

Functional subsets of helper CD4+ T cells carry TCR repertoires with distinct features that are reproducible across donors and are partially acquired at the level of thymic selection.

Spatial accuracy of grid cell firing correlates with the slope of the local field potential theta frequency vs. running speed relationship and integrates velocity signals over past time.

A widespread family of chaperones functions to stabilize membrane protein effectors by mimicking transmembrane helical environments and promotes effector export by the bacterial type VI secretion system.

The conserved chTOG protein is required to destabilize incorrect kinetochore-microtubule attachments.

Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.

Combination of experimental mouse models with single-cell RNA-sequencing creates a detailed map of medullary thymic epithelial cell development and identifies a transit-amplifying population as the immediate precursor to Aire-expressing mTECs.

An open-source software tool enables the anatomical parcellation of an unprecedented number of subcortical structures in magnetic resonance images of the human brain, automatically and in individual subjects.

Natural substrates of the central endoplasmic reticulum quality control glycoprotein sensors UDP-glucose:glycoproteinglucosyltransferase (UGGT)1 and UGGT2 were identified using a glycoproteomics approach and the role for their modification was explored.