Johannes Jacobus Fahrenfort, Philippa A Johnson ... Simon van Gaal
The neural basis of consciousness is confounded by the mismatch between what participants report about their experience versus what they actually experience.
Jingbo Kan, Adrian Morales-Amador ... Sean F Brady
Oxydifficidin presents potent activity against multidrug-resistant Neisseria gonorrhea with a new mode of action, which opens a new avenue for potentially addressing antibiotic resistant gonorrhea.
Infant attention during naturalistic social interactions is supported by their own endogenous neural activity and extended with the micro-contingent behavioural responsivity of their caregiver.
Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
Combining phylogenetic analyses and functional assays to study the receptor interacting protein kinase family reveals conserved and non-conserved functions in immune signaling across vertebrates.
Shinichi Nakagawa, William K Cornwell, Corey T Callaghan
Analysis of 3 billion bird observations finds no intrinsic abundance-occupancy relationship, overturning a famous macroecological rule and redefining approaches to biodiversity assessment and conservation.
Cryo-EM structures of HsNCX1 in complex with either phosphatidylinositol 4,5-bisphosphate (a physiological activator) or SEA0400 (a pharmacological inhibitor) provide mechanistic insights into the cellular regulation and pharmacology of NCX proteins.
Leafhoppers evade predators using nanostructured brochosomes that reduce ultraviolet reflectance through morphology shaped by four novel structural proteins originating from evolutionary duplication–divergence processes.
Hemodynamic occlusion introduces a spatially heterogenous confound to activity measurements using two-photon and widefield imaging in mouse cortex, and needs to be taken into consideration when interpreting functional imaging data.
Joanna Kosinska, Julian C Assmann ... Markus Schwaninger
The therapeutic effect of dimethyl fumarate in experimental autoimmune encephalomyelitis depends on the diet of mice and is mediated by the G protein-coupled receptor HCAR2 in neutrophils.
Madeline M Keenen, Liheng Yang ... Carolyn B Coyne
Trophoblast organoids recapitulate syncytiotrophoblast nuclear heterogeneity and reveal environment-dependent gene regulation critical for placental hormone production and differentiation.
