Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
Household clustering and seasonal parasite dynamics highlight the need to target asymptomatic carriers for community-based malaria elimination strategies.
A single protein can switch cellular behaviors from protrusion to retraction based on its concentration and dynamics, revealing a novel mechanism for controlling antagonistic phenotypes in cell signaling.
Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
Targeting EMC10 restores neuronal function in 22q11.2DS patient-derived neurons and reverses cognitive deficits in adult mice, highlighting its potential as a therapeutic strategy for mitigating disease-related cognitive impairments.
Precise protein quality control in the endoplasmic reticulum is crucial for Cryptococcus neoformans pathogenicity by modulating glycoprotein processing and extracellular vesicle-mediated transport of virulence factors.
Robert G Stewart, Matthew James Marquis ... Jon T Sack
Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.
IFN-β-induced WTAP phase transition bridges STAT1 and MTC, which orchestrates m6A dynamics on ISG mRNAs to suppress excessive immune response and sustain immune homeostasis.