Browse our Research Articles

Page 737 of 1,392
    1. Neuroscience

    Three-dimensional synaptic organization of the human hippocampal CA1 field

    Marta Montero-Crespo, Marta Dominguez-Alvaro ... Lidia Blazquez-Llorca
    Volume electron microscopy reveals the synaptic organization of the neuropil of the human hippocampal CA1 field.
    1. Neuroscience

    Phylogenetic variation in cortical layer II immature neuron reservoir of mammals

    Chiara La Rosa, Francesca Cavallo ... Luca Bonfanti
    The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of large cargo transport into the nucleus

    Giulia Paci, Tiantian Zheng ... Edward A Lemke
    Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
    1. Biochemistry and Chemical Biology

    Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

    Nicole L Jenkins, Simon A James ... Gawain McColl
    As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Emergence and diversification of a host-parasite RNA ecosystem through Darwinian evolution

    Taro Furubayashi, Kensuke Ueda ... Norikazu Ichihashi
    In an in vitro RNA replication system, an RNA spontaneously diversifies and continuously evolves through coevolution with parasitic entities.
    1. Biochemistry and Chemical Biology

    Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

    Januka S Athukoralage, Stuart McQuarrie ... Malcolm F White
    A widespread ribonuclease is a CRISPR-associated ring nuclease with a highly unusual cooperative mechanism involving tetramerisation of the enzyme.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The role of Rif1 in telomere length regulation is separable from its role in origin firing

    Calla B Shubin, Carol W Greider
    Telomere length is linked to DNA replication, and we found excessive telomeric origin firing caused by several distinct mutants did not lengthen telomeres, narrowing possible mechanisms.
    1. Neuroscience

    Consistent patterns of distractor effects during decision making

    Bolton KH Chau, Chun-Kit Law ... Matthew FS Rushworth
    The value of any choice is not static but dynamically changes as a function of the context of the alternatives even if they are seemingly irrelevant.
    1. Medicine

    Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors

    AJ Venkatakrishnan, Arjun Puranik ... Venky Soundararajan
    SARS-CoV-2 receptor ACE2 is expressed in nasal olfactory epithelia, tongue keratinocytes and small intestine enterocytes, connected with the COVID-19 patient phenotypes such as anosmia and diarrhea.
    1. Neuroscience

    Learning-related population dynamics in the auditory thalamus

    Ariel Gilad, Ido Maor, Adi Mizrahi
    The auditory thalamus encodes higher-order information that emerges while learning an auditory discrimination task.