Browse our Research Articles

Page 753 of 1,395
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase

    John Z Chen, Douglas M Fowler, Nobuhiko Tokuriki
    Comprehensive mutational characterisation of VIM-2 metallo-beta-lactamase deciphered the residues responsible for key functional behavior, including translocation, stability, substrate recognition and catalysis.
    1. Neuroscience

    Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

    Magali Macchi, Karine Magalon ... Pascale Durbec
    Heparan sulfate synthesis by mature oligodendrocytes creates a protective and permissive environment controling microglia and oligodendrocyte progenitors reactivation during remyelination.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes

    Alisha Schlichter, Margaret M Kasten ... Bradley R Cairns
    A SWI/SNF-family chromatin remodeling subcomplex from yeast is identified (RSC1) that is specialized to slide nucleosomes residing on DNA sequences that confer partial nucleosome unwrapping, with assistance from accessory factors.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

    Claire Y Ma, John C Marioni ... Arianne C Richard
    The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.
    1. Ecology

    A moth odorant receptor highly expressed in the ovipositor is involved in detecting host-plant volatiles

    Rui-Ting Li, Ling-Qiao Huang ... Chen-Zhu Wang
    A moth can detect plant volatiles using an odorant receptor expressing in its ovipositor, and this odorant receptor has a much higher expression level in the ovipositor than antennae.
    1. Medicine
    2. Neuroscience

    Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

    Jianxi Zhu, Gehua Zhen ... Xu Cao
    Osteoblastic PGE2 induces pain and OA progression by NaV1.8 modification and serves as a potential target multiple skeletal pain and degenerations.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Microbiology and Infectious Disease

    A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

    Aurélia C Balestra, Mohammad Zeeshan ... Mathieu Brochet
    Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.
    1. Neuroscience

    The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information

    Takahiro Doi, Yunshu Fan ... Long Ding
    Caudate neurons encode reward and sensory information and the effects of caudate microstimulation mimic the monkeys' voluntary reward bias strategy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia

    Santosh Kumar Kuncha, Vinitha Lakshmi Venkadasamy ... Rajan Sankaranarayanan
    Identification of a two-tier functional redundancy to combat proteostasis imbalance induced due to tRNA expansion and oxidative stress in multicellular animals.