Browse our Research Articles

Page 758 of 1,394
    1. Neuroscience

    A Bayesian and efficient observer model explains concurrent attractive and repulsive history biases in visual perception

    Matthias Fritsche, Eelke Spaak, Floris P de Lange
    Attractive and repulsive history biases in visual perception occur simultaneously, yet over dissociable timescales, and are explained by efficient encoding and Bayesian decoding of visual information in a stable environment.
    1. Neuroscience

    The neurons that mistook a hat for a face

    Michael J Arcaro, Carlos Ponce, Margaret Livingstone
    Neuronal recordings reveal complex, heterogeneous inputs to face-selective neurons, suggesting that inferotemporal neurons do not represent objects in isolation, but are also sensitive to object relationships that reflect environmental regularities.
    1. Biochemistry and Chemical Biology

    CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

    Joshua C Cofsky, Deepti Karandur ... Jennifer A Doudna
    The DNA flanks on either side of an R-loop differ in stability, and CRISPR-Cas12 enzymes form double-strand breaks by targeting the more unstable flank with their single DNase active site.
    1. Developmental Biology
    2. Neuroscience

    Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation

    Emily Ling-Lin Pai, Jin Chen ... John LR Rubenstein
    Maf and Mafb differentially regulate MGE-derived cortical and hippocampal interneuron subtype and regional fate in part through promoting the expression of Mef2c and Pnoc during mouse embryonic neurogenesis.
    1. Epidemiology and Global Health

    Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

    Daniel W Belsky, Avshalom Caspi ... Terrie E Moffitt
    Methylation pace of aging is a novel measure requiring only a blood sample that clinical-trial and observational studies can use to test if treatments modify how fast participants are aging.
    1. Neuroscience

    Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

    David Moreno-Delgado, Mar Puigdellívol ... Peter J McCormick
    Progression of Huntington's disease can be slowed by altering dopamine signalling through the Dopamine 1 receptor - Histamine 3 receptor heteromer.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family

    Aisling Y Coughlan, Lisa Lombardi ... Kenneth H Wolfe
    A family of homing genetic elements that look like inteins but work differently is the progenitor of the endonuclease that enables Saccharomyces cerevisiae to change its mating type.
    1. Structural Biology and Molecular Biophysics

    Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

    Eshwar R Tammineni, Natalia Kraeva ... Eduardo Rios
    Calcium-driven protein changes, causing glycogenolysis, poor synthesis, and diminished content of glycogen, along with diminished glucose transporters, lead to hyperglycemia in patients prone to calcium leaks from intracellular muscle stores.
    1. Chromosomes and Gene Expression

    Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

    Ava C Carter, Jin Xu ... Howard Y Chang
    A long noncoding RNA uses viral mimicry to achieve developmental gene silencing across a chromosome.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

    Chen Bao, Sarah Loerch ... Dmitri N Ermolenko
    By sterically hindering tRNA binding and inhibiting translation elongation, mRNA stem-loops can modulate gene expression.