Joseph A Giovinazzo, Russell P Thomson ... Ryan Schreiner
Cytotoxicity associated with APOL1 renal-risk variants occurs through its plasma-membrane localization, where aberrant channel activity drives a sustained sodium and calcium influx leading to cell swelling and eventually cell death.
Jennifer Orthmann-Murphy, Cody L Call ... Dwight E Bergles
Regeneration of oligodendrocytes in the cerebral cortex results in reorganization of the pattern of myelination, potentially impacting information processing within cortical networks in diseases such as multiple sclerosis.
Jeremiah Keyes, Ambhighainath Ganesan ... Jin Zhang
An individual extracellular signal regulates multiple cellular actions through differences in the temporal dynamics of spatially distinct populations of the central signaling enzyme, extracellular-signal regulated kinase.
Benjamin G Butt, Danielle J Owen ... Stephen C Graham
A conserved viral protein complex that promotes membrane wrapping of nascent herpesvirus particles shows structural similarity to cellular membrane-remodelling proteins, suggesting functional mimicry.
Development of a real-time SnRK2 kinase FRET reporter reveals rapid SnRK2 activation by ABA, but not by Methyl-Jasmonate or elevated CO2, while directly demonstrating basal SnRK2 activity in guard cells.
Computational approach to identify reproducible genetic interactions in cancer reveals that they are enriched among protein–protein interaction pairs.
Alexandre LS Filipowicz, Christopher M Glaze ... Joshua I Gold
Pupil-linked arousal dynamics are influenced more strongly by high-level internal belief states than by low-level sensory events during decision-making.
Unbiased ChIP-seq screens and genetic knockouts of large Kruppel associated box zinc finger protein (KRAB-ZFP) clusters reveal that evolutionarily young KRAB-ZFPs play a redundant role in retrotransposon restriction in mice.
