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    1. Ecology
    2. Evolutionary Biology

    Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

    Adrián Moreno Borrallo, Sarahi Jaramillo Ortiz ... Francois Criscuolo
    Bird species with higher plasma glucose show comparatively lower albumin glycation, suggesting the evolution of glycation resistance mechanisms, and terrestrial carnivores present higher glycation than omnivores.
    1. Stem Cells and Regenerative Medicine

    Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

    Xiexiang Shao, Xingzuan Lin ... Ping Hu
    Tendon regeneration is supported by human CD29+/CD56+ myogenic progenitors through tenogenic differentiation, representing a distinct stem cell population with therapeutic potential.
    1. Neuroscience

    Viral-mediated Pou5f1 (Oct4) overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia

    Nguyet Le, Sherine Awad ... Seth Blackshaw
    Viral-mediated Oct4 overexpression induces direct conversion of wildtype mammalian Müller glia to bipolar neurons, and this process is synergistically enhanced by loss of Notch signaling.
    1. Neuroscience

    Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

    Rashi Pant, Kabilan Pitchaimuthu ... Brigitte Röder
    Rare individuals treated for congenital cataracts demonstrated shifts in the visual cortex’s excitatory/inhibitory balance even decades post-surgery, reflected by alterations in the neurotransmitter concentration ratio and aperiodic electroencephalogram activity.
    1. Computational and Systems Biology
    2. Ecology

    Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

    Iva Veseli, Yiqun T Chen ... A Murat Eren
    Higher biosynthetic capacity of gut microbes in individuals diagnosed with noncommunicable diseases or taking antibiotics suggests that diversity loss and 'dysbiosis' result from microbiome restructuring in response to ecosystem disruption.
    1. Cell Biology

    Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions

    Katarzyna Tutak, Izabela Broniarek ... Krzysztof Sobczak
    Identification of ribosomal proteins RPS26 and RPS25, along with chaperone TSR2, as new important modifiers in the noncanonical translation process linked to fragile X premutation disorders.
    1. Cell Biology
    2. Medicine

    AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

    Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong
    AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
    1. Cell Biology

    scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia

    Shimin Wang, Hongxian Wang ... Dong Zhao
    The specific interaction between Sertoli cell subtypes and germ cell subpopulations mediates spermatogenesis disorders in non-obstructive azoospermia.
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    1. Computational and Systems Biology
    2. Neuroscience

    Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

    Lili Karashchuk, Jing Shuang Li ... Bingni W Brunton
    A model that simulates realistic fly walking uses an anatomically-inspired layered architecture to achieve robust walking, quantifying the tolerance of this circuit to sensorimotor delays.
    1. Neuroscience

    Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats

    Tudor M Ionescu, Mario Amend ... Kristina Herfert
    PET molecular connectivity is feasible, plausible, and delineates brain-wide pharmacologic effects not identified by BOLD functional connectivity.