State anxiety alters the dynamics of beta oscillations during reward-dependent motor learning, thereby impairing proper updating of motor predictions when learning in unstable environments.
Cristina Olivieri, Yingjie Wang ... Gianluigi Veglia
A combination of NMR, fluorescence, and molecular dynamics simulations reveals the recognition mechanism for the intrinsically disordered regulator of protein kinase A, highlighting the enzyme's nuclear export process.
Oliver W Bayfield, Alasdair C Steven, Alfred A Antson
Structure of the portal protein of a thermostable virus, determined in its capsid-bound state, reveals a molecular mechanism that prevents DNA slippage during genome packaging.
A library of the paired peptide/HLA multimers and artificial APCs allows for construction of a large database of class I-restricted peptides and cognate tumor-reactive TCR genes at an unprecedented scale.
Francesco Vacca, Caroline Chauché ... Henry J McSorley
HpBARI is a protein secreted by a parasitic helminth, which binds to and blocks the IL-33 receptor, suppressing IL-33-dependent type 2 immune responses.
Charles E MacKay, M Dennis Leo ... Jonathan H Jaggar
PKD2 (polycystin-2) channels are a major component of a flow-sensing signaling mechanism in endothelial cells that stimulates vasodilation and reduces blood pressure.
Nicolò Tosetti, Nicolas Dos Santos Pacheco ... Dominique Soldati-Favre
A combination of high-resolution microscopy and reverse genetics identified key components of the alveolin network playing an essential role in the assembly of subpellicular microtubules and conoid in Toxoplasma gondii..
Valerie PI Vidal, Fariba Jian-Motamedi ... Andreas Schedl
In the developing kidney, secreted molecules of the R-spondin family control progenitor cell proliferation and nephron formation by permitting WNT/β-catenin signalling.