Virapat Kieuvongngam, Paul Dominic B Olinares ... Jue Chen
Cryo-EM structure of a peptidase-containing ABC transporter in complex with its protein substrate reveals a mechanism of coupling substrate cleavage to translocation.
Single molecular imaging of MeCP2 at high spatial/temporal resolution identifies distinct structural domains contributing to its dynamic behaviors and chromatin interactions in live neurons.
Wenchang Zhou, Giacomo Fiorin ... José D Faraldo-Gómez
The conformational mechanism of a transporter protein is found to have profound and energetically costly effects on the morphology of the surrounding membrane.
Celso M Teixeira-Duarte, Fátima Fonseca, João H Morais-Cabral
Cations are essential cofactors in the ATP activation mechanism of the KtrAB cation channel and appear to be cofactors of many other nucleotide-dependent RCK domains.
Self-reactive thymocyte death is most efficient when peptide-presenting cells are phagocytic, and blocking phagocytosis inhibits self-reactive thymocyte death, suggesting that phagocytes play central roles during thymocyte negative selection.
Machine learning and experimental tests of receiver bias identify signal components critical to correct species classification in guenons, linking face pattern diversity to selection for species discrimination.
Ivana Strazic Geljic, Paola Kucan Brlic ... Tihana Lenac Rovis
Single mouse cytomegalovirus protein, m154, downmodulates surface expression of numerous targets important for NK and CD8 T cell activation by perturbing adaptor protein-1 sorting and redirecting targets to lysosomal degradation.
Sergey D Stavisky, Francis R Willett ... Jaimie M Henderson
Neurons in human dorsal motor cortex, an area involved in controlling arm and hand movements, are also active – and show similar ensemble dynamics – during speaking.
