Browse our Research Articles

Page 819 of 1,426
    1. Neuroscience

    Cortical state transitions and stimulus response evolve along stiff and sloppy parameter dimensions, respectively

    Adrian Ponce-Alvarez, Gabriela Mochol ... Gustavo Deco
    Neurons differ in their impact on collective cortical activity, with sensitive neurons forming a stable topological core, implicated in cortical-state transitions, while peripheral insensitive neurons are more responsive to stimuli.
    1. Neuroscience

    Temporal chunking as a mechanism for unsupervised learning of task-sets

    Flora Bouchacourt, Stefano Palminteri ... Srdjan Ostojic
    Model-based analyses of human behaviour and neural activity show that representations of concurrent task-sets emerge by merging together representations of individual stimulus-response associations that occur in temporal proximity.
    1. Biochemistry and Chemical Biology

    Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

    Susanne Gerndt, Cheng-Chang Chen ... Christian Grimm
    The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.
    1. Neuroscience

    Categorical representation from sound and sight in the ventral occipito-temporal cortex of sighted and blind

    Stefania Mattioni, Mohamed Rezk ... Olivier Collignon
    The categorical organization of the ventral occipito-temporal cortex, typically thought to be a visual region, is actually partially independent of visual input and even visual experience.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

    Kevin Michalski, Johanna L Syrjanen ... Toshimitsu Kawate
    The structure of a pannexin 1 uncovers the extracellular loops of pannexin 1 as important structural motifs for ion selectivity and channel inhibition.
    1. Cancer Biology

    GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

    Daiki Kato, Tomonori Yaguchi ... Yutaka Kawakami
    The safety and strong antitumor effects of GPC1-specific CAR-T cells against GPC1-expressing solid tumors were demonstrated by using both syngeneic and xenogeneic mouse models.
    1. Neuroscience

    Visually-updated hand state estimates modulate the proprioceptive reflex independently of motor task requirements

    Sho Ito, Hiroaki Gomi
    Distortion and elimination of limb visual feedback affects low-level stretch reflex control, indicating the involvement of a high-level and multimodal representation of the limb state in orchestrating hierarchical sensorimotor control.
    1. Cell Biology
    2. Developmental Biology

    Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

    Emilie Guillon, Dipjyoti Das ... Scott Holley
    A fibronectin matrix constantly remodels to the area of highest mechanical stress, and the resulting fibronectin-mediated inter-tissue adhesion impedes neural tube convergence.
    1. Developmental Biology

    Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling

    Hua Shen, Peiheng Gan ... Henry M Sucov
    Neonatal mouse heart regeneration relies on the presence of mononuclear diploid cardiomyocytes, which unites this process with embryonic heart growth and adult heart regeneration.
    1. Immunology and Inflammation

    Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

    Alok Kumar, Kenji Chamoto ... Tasuku Honjo
    Downregulation of mitochondrial activity by immunosuppressive tumor-derived soluble factors leads to systemic unresponsiveness to the PD-1 blockade therapy.