During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.
Valeria Sulzyk, Ludmila Curci ... Patricia S Cuasnicu
The identification of epididymal proteins relevant for sperm DNA integrity and early embryo development will contribute to a better understanding, diagnosis, and treatment of human infertility.
Mohsen Khosravi-Maharlooei, Andrea Vecchione ... Megan Sykes
Functional analyses identify Tfh-like and Tph-like CD4+ T cells as drivers of a spontaneous autoimmune syndrome characterized by autoreactive B cells in human immune system mice.
Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.
Ida Marie Boisen, Nadia Krarup Knudsen ... Martin Blomberg Jensen
Testicular microcalcifications arise secondary to local alterations in mineral homeostasis, which in combination with impaired Sertoli cell function and reduced levels of mineralization inhibitors facilitate deposition of hydroxyapatite.
Islet cholesterol levels determine GLP-1R function, with several cholesterol-binding sites mapped in active vs inactive receptors and one, containing Val229, shown to control GLP-1R behaviour in beta cell models.
Disruption of RAS–p110α signalling in macrophages impairs both the initiation and resolution of inflammatory responses, revealing a critical regulatory role in immune function and inflammation control.
Franziska Auer, Katherine Nardone ... David Schoppik
Purkinje cells influence postural control in developing zebrafish, revealing age-dependent cerebellar contributions to balance and establishing a powerful model for studying cerebellar control of postural maturation.
