Martina Rudgalvyte, Zehan Hu ... Dominique A Glauser
Phosphoproteomics identifies diverse CaM kinase substrates, while genetic dissection reveals an unexpected antagonistic interaction with calcineurin signaling that operates in distinct neurons to regulate thermo-nociception in Caenorhabditis elegans.
Transcriptional regulatory network models can aid in identifying candidate genes associated with the target phenotype in bacterial genome-wide association studies.
Mia L Abramsson, Robin A Corey ... Michael Landreh
Bulding a cardiolipin binding site into a computationally designed transmembrane protein uncovers how proteins can recognize specific lipids and use them to regulate their function.
Giuseppe Deganutti, Ludovico Pipito ... Christopher Arthur Reynolds
Multiple walker supervised molecular dynamics simulations deliver insights on glucagon-like peptide 1 receptor activation, Gs protein binding, and guanosine diphosphate release from the Gsα subunit using an adaptive sampling approach.
A novel midline barrier is discovered in the developing gut, highlighting its dynamics and function, with broad implications for patterning mechanisms, extracellular matrix significance, and laterality disorders.
To better understand how olfactory ensheathing cells modify spinal cord injury sites, single-cell RNA-sequencing was used to identify five OEC subtypes, progenitors, and novel genes associated with axonal outgrowth.
Behavioral experiments provide strong evidence that krill swimming behavior is controlled by biological clocks throughout the year, revealing a key mechanism for adaptation to high-latitude habitats.
William Hockeimer, Ruo-Yah Lai ... James J Knierim
Place cells that show repeating place fields in geometrically similar locations of an environment modulate their firing rates differently in each field based on movement direction.
