Rgs12 protein is a novel regulator of the Nrf2 protein by facilitating the proteasomal degradation of the transcription factor during osteoclast differentiation.
Interactions between the voltage sensor and intracellular domains modulate voltage-dependent gating and calmodulin inhibition in the voltage-gated potassium channel Eag1.
Morayma M Temoche-Diaz, Matthew J Shurtleff ... Randy Schekman
Biochemical fractionation of vesicle sub-populations and in vitro reconstitution studies reveal that Lupus La protein mediates the selective sorting of miR-122 into extracellular vesicles in vitro and in vivo.
Yelena D Kulik, Deborah J Watson ... Kristen M Harris
The secretory and recycling components of neuronal dendrites, smooth endoplasmic reticulum and endosomes, were discovered to support synaptogenesis underlying a cellular mechanism of learning and memory in the developing brain.
Huy Quoc Nguyen, Jagoree Roy ... Polly Morrell Fordyce
A novel high-throughput method for measuring many weak protein-peptide affinities simultaneously reveals how calcineurin, a human phosphatase essential for the immune response, recognizes its peptide substrates.
Bernadette O'Donovan, Adewale Adeluyi ... Pavel I Ortinski
Low effort-based motivation to pursue naturally rewarding stimuli can be increased pharmacologically, by targeting inactivation of a single voltage-gated potassium channel within the mesolimbic dopamine reward system.
β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
Leanne M Holt, Raymundo D Hernandez ... Michelle L Olsen
Brain-derived neurotrophic factor (BDNF)/TrkB.T1 signaling contributes to astrocyte morphological maturation, with implications for neuronal synaptogenesis and function and astrocyte functional maturation.
