Browse our Research Articles

Page 856 of 1,383
    1. Cell Biology
    2. Developmental Biology

    CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

    Myo-Hyeon Park, Ae kyung Kim ... You Mie Lee
    Cyr61 autoregulating tip cell activity by interlinking integrin and Hippo pathway and targeting Cyr61 provides promising therapeutic approach for the treatment of pathological angiogenesis, including tumour angiogenesis.
    1. Neuroscience

    Molecular and anatomical organization of the dorsal raphe nucleus

    Kee Wui Huang, Nicole E Ochandarena ... Bernardo L Sabatini
    The dorsal raphe nucleus contains transcriptionally diverse cell classes that include subtypes of serotonergic neurons with distinct molecular and anatomical signatures.
    1. Structural Biology and Molecular Biophysics

    Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

    Emiko Uchikawa, Eunhee Choi ... Xiao-chen Bai
    The identification of the insulin binding site 2 by high resolution cryo-EM analysis.
    1. Biochemistry and Chemical Biology

    Repression of ferritin light chain translation by human eIF3

    Mia C Pulos-Holmes, Daniel N Srole ... Jamie H Cate
    Human ferritin light chain (FTL) mRNA translation is regulated via its 5'-untranslated region (5'-UTR) by three mechanisms: RNA folding, iron response protein binding, and eukaryotic translation initiation factor eIF3 binding.
    1. Neuroscience

    Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit

    Weiwei Liu, Anindya Ganguly ... Craig Montell
    Functional dissection of a cluster of male-specific neurons in Drosophila reveals a neuronal circuit regulating male courtship in accordance with the internal drive state.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

    Emil Dandanell Agerschou, Patrick Flagmeier ... Alexander K Buell
    The high affinity α-synuclein-monomer binder AS69 converts into a strong sub-stoichiometric inhibitor of nucleation processes upon formation of the AS69-α-synuclein complex, achieving reduced aggregation in vitro and in vivo.
    1. Ecology
    2. Evolutionary Biology

    Reduced metabolism supports hypoxic flight in the high-flying bar-headed goose (Anser indicus)

    Jessica U Meir, Julia M York ... William K Milsom
    Measurements of bar-headed geese flying in a wind tunnel in hypoxia reveal that these birds sustain aerobic flight at high altitude via a reduction in metabolism.
    1. Developmental Biology
    2. Evolutionary Biology

    Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

    Judith Wexler, Emily Kay Delaney ... Artyom Kopp
    Sexual differentiation controlled by sex-specific mRNA splicing evolved in a step-wise manner in insects.
    1. Genetics and Genomics

    Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade

    Tom O Delmont, Evan Kiefl ... A Murat Eren
    An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

    M Azim Ansari, Elihu Aranday-Cortes ... Vincent Pedergnana
    Interferon lambda 4, a protein part of the innate immune response, drives major amino acids selection in patients chronically infected with hepatitis C virus.