Browse our Research Articles

Page 859 of 1,445
    1. Epidemiology and Global Health

    Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

    Xia Li, Alexander Ploner ... Sara Hägg
    Biological ages have the potential to provide aging-related information beyond chronological age and can be predictive of mortality independently of both chronological age and different types of biological ages.
    1. Neuroscience

    Anatomical and single-cell transcriptional profiling of the murine habenular complex

    Michael L Wallace, Kee Wui Huang ... Bernardo L Sabatini
    Single-cell transcriptional profiling reveals distinct neuronal subtypes of the lateral habenula differentially target downstream neuronal subtypes in the ventral tegmental area and dorsal raphe nucleus.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

    Timothy R Sampson, Collin Challis ... Sarkis K Mazmanian
    Production of an amyloid protein by bacteria within the gut microbiome can influence the pathophysiology of a mouse model of synucleinopathy.
    1. Epidemiology and Global Health

    Body height in young adult men and risk of dementia later in adult life

    Terese Sara Høj Jørgensen, Gunhild Tidemann Okholm ... Merere Osler
    Taller body height in young adulthood, as marker of early-life environment, is associated with lower risk of dementia diagnosis independently of cognitive reserve and family factors shared among brothers.
    1. Neuroscience

    Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network

    Yaara Lefler, Oren Amsalem ... Yosef Yarom
    Non-synaptic electrical events recorded simultaneously from pairs of neurons in the inferior olive nucleus enables accurate estimation of the size and of the clustered organization of the electrically coupled network.
    1. Structural Biology and Molecular Biophysics

    Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

    Jonathan M Philpott, Rajesh Narasimamurthy ... Carrie L Partch
    A conformational switch in the Casein Kinase 1 activation loop controls substrate preference to regulate the abundance of the clock protein PERIOD2 and circadian timekeeping.
    1. Cell Biology
    2. Neuroscience

    Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

    Jose F Moruno-Manchon, Pauline Lejault ... Andrey S Tsvetkov
    G-quadruplex DNA regulates autophagy in neurons.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Pan-mammalian analysis of molecular constraints underlying extended lifespan

    Amanda Kowalczyk, Raghavendran Partha ... Maria Chikina
    Cancer control, DNA repair, and immunity are key functionalities underlying the evolution of extended lifespan in mammals.
    1. Neuroscience

    C1 neurons are part of the circuitry that recruits active expiration in response to the activation of peripheral chemoreceptors

    Milene R Malheiros-Lima, Josiane N Silva ... Thiago S Moreira
    An unbiased description reveals potential implications for understanding the developmental mechanisms that match respiratory supply and demand during hypoxia.
    1. Neuroscience

    Distinct roles for innexin gap junctions and hemichannels in mechanosensation

    Denise S Walker, William R Schafer
    The innexin protein UNC-7, a homologue of vertebrate pannexins, plays a specific, gap junction-independent role in C. elegans mechanosensation.