Browse our Research Articles

Page 86 of 1,455
    1. Immunology and Inflammation

    MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

    Linsey Peters, Leonida Rakateli ... Emiel van der Vorst
    Lipid nanoparticles containing microRNA-26-mimics can reduce MASH in mice, providing a novel therapeutic approach.
    1. Evolutionary Biology

    Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids

    Nagatoshi Machii, Ryo Hatashima ... Masato Nikaido
    A shared molecular basis of proteoglycan accumulation, driven by Wnt signaling, underlies the parallel evolution of hypertrophied lips in East African cichlids.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Shinichi Kawaguchi, Xin Xu ... Toshie Kai
    AlphaFold2-based large-scale screening reveals novel protein interactions, accelerating functional studies of piRNA pathway proteins and expanding bioinformatic-experimental integration.
    1. Neuroscience

    Re-focusing visual working memory during expected and unexpected memory tests

    Sisi Wang, Freek van Ede
    Memory tests evoke a second stage of internal attentional deployment following both expected and unexpected memory tests, extending attentional re-orienting to working memory.
    1. Cancer Biology
    2. Cell Biology

    Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Cell crowding drives a pro-invasive mechanotransduction pathway in high-grade DCIS, inducing TRPV4 inhibition, calcium and cell volume reduction, and increased invasion, with compensatory plasma-membrane TRPV4 relocation indicating pathway activation.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural population dynamics underlying evidence accumulation in multiple rat brain regions

    Brian DePasquale, Carlos D Brody, Jonathan W Pillow
    A computational framework for combining neural and behavioral data to infer latent dynamics underlying decision-making reveals distinct accumulation dynamics in different brain regions in the rat.
    1. Neuroscience

    Cholesterol taste avoidance in Drosophila melanogaster

    Roshani Nhuchhen Pradhan, Craig Montell, Youngseok Lee
    Fruit flies detect cholesterol through ionotropic receptors in taste, leading to active avoidance despite dietary necessity.
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Diet-induced obesity, insulin resistance, and proinflammatory macrophage activation and accumulation in adipose tissue can be counteracted through the inhibition of ER stress sensor IRE1alpha.
    1. Evolutionary Biology

    Social and environmental predictors of gut microbiome age in wild baboons

    Mauna R Dasari, Kimberly E Roche ... Elizabeth A Archie
    The mammalian gut microbiome can be used as a noninvasive and holistic predictor of biological age.
    1. Cancer Biology
    2. Genetics and Genomics

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy Lu
    Pairwise CRISPR screen identified FYN and KDM4 as key regulator of tyrosine kinase inhibitor resistance in triple negative breast cancer (TNBC).