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Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.

Chitons overcome evolutionary constraints through unprecedented genomic dynamism, with extensive chromosomal rearrangements and duplications despite about 300 million years of morphological stasis.

Understanding and reasoning about the physical world rely on a specific brain network, in which the area PF of the left inferior parietal lobe plays a central role.

Humans scale brain signal variability with stimulus complexity to efficiently process visual inputs, an ability reduced in those with poorer visual discrimination and in older adults with lower GABA levels (brain's major inhibitory neurotransmitter), but recoverable by boosting GABA pharmacologically.

Genetic tools were generated and used to determine the neurotransmitters and neuropeptides used by individual cell types within the Drosophila central complex and to study their roles in sleep regulation.

A physical modeling and its simulation showed distinctive role of surface elasticity and contractility during the apical constriction.

A game-theoretical framework for uncovering how optimal signal transmission takes place in a given network, here applied to large-scale brain networks.

High-throughput characterization of all possible CDKN2A missense variants identifies functionally deleterious variants and establishes accuracy of variant effect predictors.

Future prosocial acts can be forecasted from stable biological differences in how people perceive others' merit, pointing to novel strategies to reduce favoritism and discrimination in social situations.

Putative markers of VTA interneurons label VTA projection neurons, and VTA projection neurons make intra-VTA synapses, suggesting VTA projection neurons may mediate functions prior attributed to interneurons.