Sexually antagonistic pleiotropy involving frequency-dependent traits like mating display maintains linkage blocks like inversions as balanced polymorphisms in simulation, and may explain common inversion polymorphisms maintained at intermediate frequencies.
A comparative study of Purkinje dendrite morphology, input arrangement, and regional subtype distribution shows human cells evade constraint by cortical thickness to be both quantitatively and qualitatively distinct from mouse.
Lauren J Kreeger, Suraj Honnuraiah ... Lisa Goodrich
In the mammalian auditory brainstem, inhibitory inputs onto octopus cell dendrites enhance coincidence detection computations and support precise yet flexible temporal processing for rapid sound onsets and frequency modulations.
Christopher T Schafer, Raymond F Pauszek III ... David P Millar
The conformational dynamics and landscapes of the related chemokine receptors CXCR4 and ACKR3, revealed by single-molecule analysis, provide mechanistic insights into differences in constitutive activity, ligand promiscuity, and effector coupling.
Graham L Barlow, Christian M Schürch ... Paul L Bollyky
A high-parameter, spatial analysis of the pancreata of individuals with type 1 diabetes reveals specific patterns of immune infiltration into islets of Langerhans, coordinated with changes in the surrounding tissue.
Phillip P Witkowski, Lindsay JH Rondot ... Erie Boorman
Orbitofrontal cortex and hippocampus reinstate representations of causal choices to associate with delayed outcomes, and the frontal pole supports this credit assignment process by maintaining pending choices during interim decisions.
Hella Luksch, Felix Schulze ... Angela Rösen-Wolff
TNF signaling contributes significantly to pathology of constitutively active STING in murine STING-associated vasculopathy with onset in infancy disease.
Mammalian condensed chromosomes exhibit diverse structural properties, as reflected in their varying stiffness across different cell stages and with aging.
