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The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.

Viewing a jumbled word activates an efficient visual representation in high-level visual cortex that is matched to stored words in the word form area.

Retrieval practice strongly engages the medial prefrontal cortex to integrate and differentiate memory representations, resulting in more effective memory updating.

Alcohol modifies dopaminergic microcircuits required for acquisition and expression of sensory memories in Drosophila resulting in a shift in behavioral response from malleable to inflexible.

The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.

The A1 of ferrets and mice show similar tonotopic organizations, with neurons preferring a single frequency being more precisely organized into a tonotopic map than multipeaked neurons.

Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.

The bond-based adhesion model is a key step toward a realistic description of RBC-parasite interaction, which allows the investigation of more realistic scenarios and is relevant for other biological systems.

Single cell RNA, protein and electrophysiology data revealed that combinatorial availability of three auxiliary subunit isoforms of a single ion channel is sufficient for generating distinct, input frequency-sensitive firing phenotypes.

Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.