Browse our Research Articles

Page 876 of 1,521
    1. Neuroscience

    Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells

    Ryan J Vaden, Jose Carlos Gonzalez ... Linda Overstreet-Wadiche
    Fast-spiking parvalbumin-expressing interneurons generate slow spillover-mediated GABAergic transmission to young adult-born and neighboring mature neurons of the dentate gyrus.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji, Kristen L Howell ... Alice H Huang
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.
    1. Biochemistry and Chemical Biology

    Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

    Fanbiao Meng, Minxian Qian ... Baohua Liu
    SIRT1 deacetylates SIRT6 at K33 to facilitate DNA double-strand breaks-recognition, subsequent expansion and local chromatin remodeling.
    1. Ecology

    Vessel noise levels drive behavioural responses of humpback whales with implications for whale-watching

    Kate R Sprogis, Simone Videsen, Peter T Madsen
    Controlled exposure experiments reveal that underwater vessel noise level from a motorised vessel is an adequate driver of behavioural disturbance in humpback whales.
    1. Developmental Biology

    A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation

    André Dias, Anastasiia Lozovska ... Moises Mallo
    During vertebrate axial extension, the tail bud originates from the activation of a developmental module in a subset of axial progenitors, concurrent but different to gastrulation.
    1. Neuroscience

    Inhibition stabilization is a widespread property of cortical networks

    Alessandro Sanzeni, Bradley Akitake ... Mark H Histed
    The strongly coupled theoretical regime describes the function of mouse sensory and motor cortical areas.
    1. Neuroscience

    mPFC spindle cycles organize sparse thalamic activation and recently active CA1 cells during non-REM sleep

    Carmen Varela, Matthew A Wilson
    Sleep spindles provide a temporal framework to organize the reactivation of behaviorally relevant CA1 cells and sparsely active cells in the limbic thalamus.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

    Claudia C Schmidt, Vedran Vasic, Alexander Stein
    Doa10, a membrane-embedded ubiquitin ligase, facilitates the removal of membrane proteins from the endoplasmic reticulum and cooperates with the Cdc48 ATPase in this process.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Slightly beneficial genes are retained by bacteria evolving DNA uptake despite selfish elements

    Bram van Dijk, Paulien Hogeweg ... Nobuto Takeuchi
    Horizontal gene transfer (HGT) helps slightly beneficial genes persist in microbial populations, incentivising cells to invest in costly DNA uptake, even in the presence of harmful selfish genetic elements.
    1. Neuroscience

    Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

    Zhigang Shi, Nicole E Pelletier ... Virginia L Brooks
    Leptin acts in the paraventricular nucleus to slowly increase sympathetic nerve activity to skeletal muscle and brown adipose tissue via induction of its own receptor in TRH glutamatergic neurons.