Browse our Research Articles

Page 875 of 1,521
    1. Structural Biology and Molecular Biophysics

    Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation

    Victor Tobiasson, Alexey Amunts
    The ciliate mitoribosome structure provides new insights into the diversity of translation and its evolution.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

    Senem Aykul, Richard A Corpina ... Vincent Idone
    The non-signaling complex formed by Activin A and ACVR1 is operant in vivo and is required to temper the degree of heterotopic ossification in the genetic disorder fibrodysplasia ossificans progressiva.
    1. Neuroscience

    PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

    Clément Menuet, Angela A Connelly ... Andrew M Allen
    The PreBötzinger complex, which contains neurons that are the kernel for inspiratory rhythm generation, also contains sympathoexcitatory and parasympathoinhibitory neurons that drive respiratory-phase oscillations in blood pressure and heart rate.
    1. Neuroscience

    Paranoia as a deficit in non-social belief updating

    Erin J Reed, Stefan Uddenberg ... Philip R Corlett
    Paranoia is underwritten by variation in prior beliefs about how the world will change and how to learn from those changes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

    Yohei Ohashi, Shirley Tremel ... Roger L Williams
    The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants

    Allison L Hicks, Stephen M Kissler ... Yonatan H Grad
    Sampling informed by pathogen genomic data may facilitate more efficient detection of novel antibiotic resistance than random sampling.
    1. Microbiology and Infectious Disease

    HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets

    Meng Hu, Guohua Yang ... Charles J Russell
    Infection experiments in ferrets reveal swine influenza viruses need their hemagglutinin antigen to become stabilized for transmissibility, adding a new property to consider when triaging field isolates for pandemic potential.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

    Louise Menendez, Talon Trecek ... Neil Segil
    Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
    1. Neuroscience

    Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells

    Ryan J Vaden, Jose Carlos Gonzalez ... Linda Overstreet-Wadiche
    Fast-spiking parvalbumin-expressing interneurons generate slow spillover-mediated GABAergic transmission to young adult-born and neighboring mature neurons of the dentate gyrus.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

    Deepak A Kaji, Kristen L Howell ... Alice H Huang
    TGFß signaling regulates migration of tenogenic cells from Scx- and non-Scx lineages and is required for functional regeneration after neonatal tendon injury.