Wei-Yun Lai, Sheng-Kai Hsu ... Christian Schlötterer
Evolved gene expression changes in Drosophila simulans uncovered the interplay between parallel evolution, polymorphism, and pleiotropy and indicated that both direct and indirect effects of pleiotropy contribute to parallel evolution.
In a mouse model of the hotspot mutant TP53Y220C, the mutant p53 exhibited oncogenic gain of function in males and teratogenic gain of function in females, both correlated with inflammation.
Carlos A Sánchez-León, Guillermo Sánchez-Garrido Campos ... Javier Márquez-Ruiz
The neuromodulatory effects of cerebellar tDCS depend on Purkinje cell somatodendritic orientation relative to the electric field, revealing a key factor for optimizing stimulation protocols and computational models.
Artem K Velichko, Nadezhda V Petrova ... Omar L Kantidze
Treacle condensation, driven by alternating charge blocks, facilitates interactions with transcription factors to spatially segregate ribosomal RNA synthesis and processing, while also recruiting TOPBP1 for activation of the rDNA damage response.
Hippocampal sharp wave-ripples during sleep are enhanced by food intake in a calorie-dependent manner and are associated with increased activity of lateral hypothalamic GABAergic neurons.
Aleksandra Prochera, Anoohya N Muppirala ... Meenakshi Rao
Genetic depletion of enteric glia in vivo disrupts antimicrobial peptide secretion by Paneth cells to change fecal microbial composition but does not broadly alter other intestinal programs.
Oscar homologs play a conserved role in Wolbachia-induced male-killing in Lepidoptera but not in other insects, highlighting the evolution of diverse male-killing mechanisms induced by Wolbachia.
A subset of hippocampal place cells, which is phase-locked to fast gamma rhythms, compressively encodes information at precessing slow gamma phases and therefore predominates to theta sequence development.
