Browse our Research Articles

Page 978 of 1,399
    1. Neuroscience

    Adaptation after vastus lateralis denervation in rats demonstrates neural regulation of joint stresses and strains

    Cristiano Alessandro, Benjamin A Rellinger ... Matthew C Tresch
    The adaptation strategy used by the nervous system following muscle paralysis restores task performance while minimizing the stresses and strains within a joint.
    1. Neuroscience

    Causal contribution and dynamical encoding in the striatum during evidence accumulation

    Michael M Yartsev, Timothy D Hanks ... Carlos D Brody
    Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.
    1. Medicine
    2. Neuroscience

    Prognostication of chronic disorders of consciousness using brain functional networks and clinical characteristics

    Ming Song, Yi Yang ... Tianzi Jiang
    Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.
    1. Cancer Biology
    2. Medicine

    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

    Haley Hieronymus, Rajmohan Murali ... Charles L Sawyers
    The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
    1. Cell Biology

    Cyclin-dependent kinase control of motile ciliogenesis

    Eszter K Vladar, Miranda B Stratton ... Jeffrey D Axelrod
    Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
    1. Developmental Biology

    An intrinsic cell cycle timer terminates limb bud outgrowth

    Joseph Pickering, Constance A Rich ... Matthew Towers
    Size control in limbs is an intrinsically determined process.
    1. Developmental Biology
    2. Cell Biology

    Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

    Ariel M Pani, Bob Goldstein
    Free, extracellular dispersal of Wnt proteins generates a long-range gradient during animal development and is required for signaling.
    1. Microbiology and Infectious Disease

    Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins

    Aaron G Wexler, Whitman B Schofield ... Andrew L Goodman
    The human gut bacterial lipoprotein BtuG binds vitamin B12 with femtomolar affinity, can remove vitamin B12 from human intrinsic factor, and is required for commensal fitness in the gut.
    1. Chromosomes and Gene Expression

    Six domesticated PiggyBac transposases together carry out programmed DNA elimination in Paramecium

    Julien Bischerour, Simran Bhullar ... Mireille Bétermier
    The machinery that carries out programmed DNA rearrangements is composed of domesticated transposases. One is catalytically active, five play architectural function essential for the accuracy of the process.
    1. Ecology

    Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly

    Inés Martínez, Maria X Maldonado-Gomez ... Jens Walter
    Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.