Mammalian cells were engineered to synthesize valine, a metabolic capacity that had been lost from the lineage of higher eukaryotes for >500 million years.
A new combined approach using X-ray fluoroscopy and machine learning provides detailed new insights into bladder function in awake, unrestrained mice and unveils important limitations of current approaches to study bladder function.
Erica J Hutchins, Shashank Gandhi ... Marianne E Bronner
The RNA-binding protein Elavl1 directly binds to and stabilizes a single gene product—Draxin mRNA—to prevent premature delamination and maintain specification in cranial neural crest.
In the zebrafish spinal cord, mixed synapses contribute to neuronal connectivity and resting excitability, which helps explain violations of the well-known 'size principle' of recruitment.
Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta
A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.