Browse our Short Reports

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    1. Immunology and Inflammation
    2. Medicine

    Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

    Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta
    A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
    Short Report Updated
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    1. Neuroscience

    The role of anterior insular cortex inputs to dorsolateral striatum in binge alcohol drinking

    David L Haggerty, Braulio Munoz ... Brady K Atwood
    A novel brain circuit that determines how much alcohol a mouse binge drinks by complex control of drinking behavior mechanics is surveyed.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Selenocyanate derived Se-incorporation into the nitrogenase Fe protein cluster

    Trixia M Buscagan, Jens T Kaiser, Douglas C Rees
    X-ray crystal structures capture ATP-dependent chalcogenide exchange from selenocyanate at the nitrogenase Fe protein cluster in the absence of the MoFe protein, an unexpected result as the Fe protein cluster is not traditionally perceived as a site of substrate binding.
    Short Report Updated
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    1. Neuroscience

    Developmental stage-specific spontaneous activity contributes to callosal axon projections

    Yuta Tezuka, Kenta M Hagihara ... Yoshiaki Tagawa
    The developing neocortex exhibits spontaneous network activity with various synchrony levels, and such activity is selectively required during a critical developmental time window for the formation of long-range axonal projections connecting the two cortical hemispheres.
    1. Neuroscience

    TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

    Wendy Wing Sze Yue, Lin Yuan ... David Julius
    Capsaicin and other vanilloid receptor ligands alter core body temperature by perturbing central thermoregulatory pathways through activation/inhibition of TRPV1 receptors on peripheral sensory nerve fibers.
    1. Epidemiology and Global Health

    Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study

    Tom G Richardson, Grace M Power, George Davey Smith
    Genetic analyses provide evidence that adiposity influences vitamin D levels at different timepoints over the lifecourse, suggesting that associations previously reported between vitamin D deficiency and disease by conventional epidemiological studies may have been prone to confounding.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

    Fei Chen, Burcu F Darst ... Christopher A Haiman
    A previously developed multi-ancestry polygenic risk score is potentially an effective prostate cancer risk stratification tool across ancestry populations.
    Short Report Updated
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    1. Neuroscience

    A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech

    Lana Hantzsch, Benjamin Parrell, Caroline A Niziolek
    Hearing a single auditory error while speaking causes an adaptive change that corrects for that error the next time we say a word, providing empirical support for current models of speech sensorimotor adaptation and aligning speech with other motor domains.
    Short Report Updated
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    1. Neuroscience

    Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala

    Liqiang Chen, Chetan Nagaraja ... Hong-Yuan Chu
    A combination of physiological, histological, and optical approaches reveals synapse-specific function of α-synuclein in mouse brain under both normal and pathological states.
    Short Report Updated
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    1. Developmental Biology
    2. Genetics and Genomics

    Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans

    Amy K Webster, Rojin Chitrakar ... L Ryan Baugh
    A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.
    Short Report Updated
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