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The structure of the mammalian target of rapamycin complex 2 (mTORC2) reveals the architecture of the complex and explains the structural basis of rapamycin insensitivity.

During speech perception, if auditory speech is not informative the frontal cortex will enhance responses in visual regions that represent the mouth of the talker to improve perception.

Loss of BAP1 function is associated with increased sensitivity to TRAIL and other death receptor agonists in malignant mesothelioma, where this is a frequent event, with immediate and actionable therapeutic implications.

Aberrant phosphorylation of tyrosine 78 on Atoh1 via Jak2 is responsible for sonic hedgehog type medulloblastoma growths in vivo.

A mutant allele encoding a deregulated subunit of an ion channel tetramer revealed a mechanistic connection between protein heteromerization and quantitative genetic behavior.

Testing of fitness-related benefits in migratory population of European blackbirds offers confirming predictions of theoretical models on the evolution and maintenance of migration.

Regulating rod gene expression with a small molecule ligand for the orphan nuclear receptor Nr2e3 rescues photoreceptors from degeneration in a mouse model of retinitis pigmentosa.

CRISPR interference (CRISPRi), which uses small guide RNAs to target catalytically dead Cas9 protein to chromatin, disrupts existing transcription units and generates new sites for initiation and termination of transcription on both strands of DNA.

An RNA enzyme is shown to function as a reverse transcriptase, an activity thought to be crucial for the transition from RNA to DNA genomes during the early history of life on Earth.

Neurite arbors of VGluT3-expressing amacrine cells (VG3-ACs) process visual information locally uniformly detecting object motion while varying in contrast preferences; and in spite of extensive overlap between arbors of neighboring cells population activity in the VG3-AC plexus encodes stimulus positions with subcellular precision.