Biochemical, molecular, and genetic analyses show that in Drosophila the epigenetic enzyme TET does not demethylate 6mA, which is scarce in the genome, but rather acts in a catalytic-independent manner.
Gregory M Noetscher, Peter J Serano ... Sergey N Makaroff
Radio frequency heating induced during magnetic resonance procedures within patients that carry embedded passive orthopedic implants may be accurately estimated through modeling and simulation.
The hippocampus demonstrates flexible coding during memory encoding, prioritizing either distance or time information based on the specific requirements of the experiment.
Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry
Rab12 was identified as a key modulator of LRRK2-dependent Rab phosphorylation that mediates the recruitment of LRRK2 to lysosomes in response to damage.
Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.
Diego Candia-Rivera, Federico Raimondo ... Jacobo D Sitt
Brain-heart interactions under the processing of auditory irregularities could help to distinguish whether a patient is in a vegetative state or in a minimally conscious state.
Deep reinforcement model and experimental evaluations identified a small-molecule CRM1 inhibitor that can selectively ablate extranodal NK/T cell lymphoma cells.
Protein kinase dysregulation, implicated in various diseases via cell signaling pathways, can be therapeutically and experimentally managed through allosteric modulation, facilitated by a dynamic network of interactions, with computational techniques enabling precise control in live systems.
A toxin-antidote element, identified for its role as a selfish genetic element that spreads through a population by killing certain offspring, also plays a beneficial role to the host.
