Browse our Short Reports

Page 4 of 61
    1. Structural Biology and Molecular Biophysics

    Decoupling of the onset of anharmonicity between a protein and its surface water around 200 K

    Lirong Zheng, Bingxin Zhou ... Liang Hong
    The dynamical transition between a protein and its surface water is decoupled.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Medicine

    A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria

    Tumininu S Faniyan, Xinyi Zhang ... Kavaljit H Chhabra
    Targeting the interaction between the kidneys and brain may increase the efficiency of SGLT2 inhibitors to better manage type 2 diabetes.
    Version of Record
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    • Valuable
    • Solid
    1. Neuroscience

    The scheduling of adolescence with Netrin-1 and UNC5C

    Daniel Hoops, Robert Kyne ... Cecilia Flores
    Adolescent brain development involves dopamine axon growth and a coincident change in UNC5c receptor expression, both of which are responsive, in unison, to an environmental signal.
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    • Important
    • Solid
    1. Plant Biology

    Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

    Yaning Cui, Hongping Qian ... Jinxing Lin
    The phosphorylation of FLS2 may activate flg22-triggered immunity by facilitating the partitioning of FLS2 into functional AtRem1.3-associated nanodomains.
    Version of Record
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    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

    Joshua D Eaton, Jessica Board ... Steven West
    High-resolution mapping of RNA polymerase II transcripts shows that the directionality of mammalian promoters is determined by preferential transcriptional initiation and the opposing activities of Integrator and CDK9.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Rapid bacterial evaluation beyond the colony forming unit in osteomyelitis

    Qi Sun, Kimberley Huynh ... Dongqing Yang
    This time-shortened work flow improves sensitivity and specificity for the identification of bacteria in bone infections independently of bacterial culturability.
    Version of Record
    Short Report
    • Fundamental
    • Compelling
    1. Plant Biology

    Arabidopsis transcriptome responses to low water potential using high-throughput plate assays

    Stephen Gonzalez, Joseph Swift ... Joseph R Ecker
    The 'low water' agar assay provides a reliable and practical high-throughput method for studying plant molecular signaling responses to drought stress.
    Version of Record
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    • Valuable
    • Solid
    1. Genetics and Genomics

    Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions

    Weiting Zhang, Karl Petri ... Jing-Ruey Joanna Yeh
    Strategic pegRNA designs and other approaches mitigating 5' and 3' interactions within pegRNAs can often lead to substantial improvements in prime editing efficiency.
    1. Neuroscience

    Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

    Blake J Laham, Isha R Gore ... Elizabeth Gould
    Adult-born granule cell projections are necessary for CA2 network activity and retrieval of developmental social memories.
    1. Cancer Biology

    Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

    Keene L Abbott, Ahmed Ali ... Matthew G Vander Heiden
    Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.
    Version of Record
    Short Report
    • Important
    • Convincing