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Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.

Design and characterization of allosteric mutations that recapitulate TRPML1 gating and structural insights into PI(4,5)P₂ and sphingomyelin inhibition of TRPML1.

Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.

The contribution of the lateral/caudal ganglionic eminence to the pool of cortical oligodendrocyte precursor cells is minimal.

There is a systemic bias in research evaluation, i.e., disciplines with a higher proportion of women have lower evaluations and funding success for all researchers, regardless of gender.

Senescent cells release an arachidonic acid-derived electrophilic oxylipin that inhibits myoblast differentiation by covalent modification and activation of HRas.

Transient platelet accumulation supports oligodendrocyte progenitor cell differentiation during myelin repair, while sustained exposure to elevated platelet numbers hampers the generation of remyelinating cells.

The dynamical transition between a protein and its surface water is decoupled.

Targeting the interaction between the kidneys and brain may increase the efficiency of SGLT2 inhibitors to better manage type 2 diabetes.

Adolescent brain development involves dopamine axon growth and a coincident change in UNC5c receptor expression, both of which are responsive, in unison, to an environmental signal.