Browse our Short Reports

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    1. Neuroscience

    Large-scale two-photon imaging revealed super-sparse population codes in the V1 superficial layer of awake monkeys

    Shiming Tang et al.
    Two-photon imaging reveals super-sparse responses to natural images in primate V1, which carry sufficient information for discrimination of the input natural images with high accuracy.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

    Bryan A Leland et al.
    A single-cell assay reveals that the genetic rewiring that underlies PARP inhibitor resistance drives altered DNA double-strand break end resection pathway choice.
    1. Neuroscience

    Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

    Zohreh Farsi et al.
    Parallel measurements of pH gradient and membrane potential at the single vesicle level have revealed that the synaptic vesicle acidification is initiated by removal of its clathrin coat, which blocks vesicular ATPase activity.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    A robust and tunable mitotic oscillator in artificial cells

    Ye Guan et al.
    The development of a robust and tunable artificial cell-cycle system paves the way for quantitative characterization of complex clock functions.
    1. Neuroscience

    Proprioceptive and cutaneous sensations in humans elicited by intracortical microstimulation

    Michelle Armenta Salas et al.
    Electrical microstimulation of human somatosensory cortex elicited purely naturalistic proprioceptive and cutaneous sensations, with proprioceptive sensations more prominent at higher current amplitudes suggesting a relationship between amplitude and sensation type.
    1. Neuroscience

    Occurrence of long-term depression in the cerebellar flocculus during adaptation of optokinetic response

    Takuma Inoshita, Tomoo Hirano
    Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.
    1. Structural Biology and Molecular Biophysics

    Architecture of the human mTORC2 core complex

    Edward Stuttfeld et al.
    The structure of the mammalian target of rapamycin complex 2 (mTORC2) reveals the architecture of the complex and explains the structural basis of rapamycin insensitivity.
    1. Neuroscience

    Frontal cortex selects representations of the talker’s mouth to aid in speech perception

    Muge Ozker et al.
    During speech perception, if auditory speech is not informative the frontal cortex will enhance responses in visual regions that represent the mouth of the talker to improve perception.
    1. Cancer Biology
    2. Human Biology and Medicine

    Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

    Krishna Kalyan Kolluri et al.
    Loss of BAP1 function is associated with increased sensitivity to TRAIL and other death receptor agonists in malignant mesothelioma, where this is a frequent event, with immediate and actionable therapeutic implications.
    1. Cancer Biology
    2. Developmental Biology

    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth

    Tiemo J Klisch et al.
    Aberrant phosphorylation of tyrosine 78 on Atoh1 via Jak2 is responsible for sonic hedgehog type medulloblastoma growths in vivo.