Browse our Short Reports

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    1. Neuroscience

    TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

    Wendy Wing Sze Yue, Lin Yuan ... David Julius
    Capsaicin and other vanilloid receptor ligands alter core body temperature by perturbing central thermoregulatory pathways through activation/inhibition of TRPV1 receptors on peripheral sensory nerve fibers.
    1. Epidemiology and Global Health

    Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study

    Tom G Richardson, Grace M Power, George Davey Smith
    Genetic analyses provide evidence that adiposity influences vitamin D levels at different timepoints over the lifecourse, suggesting that associations previously reported between vitamin D deficiency and disease by conventional epidemiological studies may have been prone to confounding.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

    Fei Chen, Burcu F Darst ... Christopher A Haiman
    A previously developed multi-ancestry polygenic risk score is potentially an effective prostate cancer risk stratification tool across ancestry populations.
    Short Report Updated
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    1. Neuroscience

    A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech

    Lana Hantzsch, Benjamin Parrell, Caroline A Niziolek
    Hearing a single auditory error while speaking causes an adaptive change that corrects for that error the next time we say a word, providing empirical support for current models of speech sensorimotor adaptation and aligning speech with other motor domains.
    Short Report Updated
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    1. Neuroscience

    Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala

    Liqiang Chen, Chetan Nagaraja ... Hong-Yuan Chu
    A combination of physiological, histological, and optical approaches reveals synapse-specific function of α-synuclein in mouse brain under both normal and pathological states.
    Short Report Updated
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    1. Developmental Biology
    2. Genetics and Genomics

    Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans

    Amy K Webster, Rojin Chitrakar ... L Ryan Baugh
    A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.
    Short Report Updated
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    1. Genetics and Genomics
    2. Medicine

    Unbiased mosaic variant assessment in sperm: a cohort study to test predictability of transmission

    Martin W Breuss, Xiaoxu Yang ... Joseph G Gleeson
    The abundance of mosaic variants detected directly in sperm accurately predicts their transmission to concepti.
    1. Developmental Biology
    2. Evolutionary Biology

    Gill developmental program in the teleost mandibular arch

    Mathi Thiruppathy, Peter Fabian ... J Gage Crump
    Lineage tracing and genetic analysis in zebrafish show that the pseudobranch is a serial homolog of the gills arising from the jaw-forming mandibular arch, thus supporting the model that vertebrate jaws derived from an ancestral mandibular gill.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

    Weizhao Chen, Qiongping Zheng ... Mingtao Li
    Repressing astroglial PTBP1 by shRNA or antisense oligonucleotide fails to convert astrocyte to neuron including dopaminergic neuron in a 6-OHDA mouse model of PD.
    Short Report Updated
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    1. Genetics and Genomics
    2. Neuroscience

    Elevated brain-derived cell-free DNA among patients with first psychotic episode – a proof-of-concept study

    Asael Lubotzky, Ilana Pelov ... Yoav Kohn
    Liquid biopsy methods utilizing brain-specific cell-free DNA methylation markers can detect brain cell death and potentially assist early detection and monitoring of schizophrenia.
    Short Report Updated
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