Browse our Short Reports

Page 3 of 61
    1. Cell Biology

    PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

    Weihong Xiong, Maozhen Qin, Haining Zhong
    Two alternative models of PKA activation were tested in neurons, and the results support the classical model in which the catalytic subunit dissociated from the regulatory subunit upon activation.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Cell Biology

    Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

    Jessica E Schwarz, Antonijo Mrčela ... Amita Sehgal
    Blood-borne factors contribute to changes in the circadian transcriptome with age.
    Version of Record
    Short Report
    • Fundamental
    • Compelling
    1. Cell Biology

    Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

    Ewa K Bomba-Warczak, Karen M Velez ... Francesca E Duncan
    Exceptionally long-lived macromolecules in mammalian ovaries and oocytes serve as pillars for lifelong reproductive health span.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Neuroscience

    Spatial transcriptomics of meningeal inflammation reveals inflammatory gene signatures in adjacent brain parenchyma

    Sachin P Gadani, Saumitra Singh ... Pavan Bhargava
    Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    TRPML1 gating modulation by allosteric mutations and lipids

    Ninghai Gan, Yan Han ... Youxing Jiang
    Design and characterization of allosteric mutations that recapitulate TRPML1 gating and structural insights into PI(4,5)P2 and sphingomyelin inhibition of TRPML1.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

    Yuqi Cai, Zhirong Zhao ... Miao He
    Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Lateral/caudal ganglionic eminence makes limited contribution to cortical oligodendrocytes

    Jialin Li, Feihong Yang ... Zhuangzhi Zhang
    The contribution of the lateral/caudal ganglionic eminence to the pool of cortical oligodendrocyte precursor cells is minimal.
    Version of Record
    Short Report
    • Valuable
    • Solid
    1. Physics of Living Systems

    Female-dominated disciplines have lower evaluated research quality and funding success rates, for men and women

    Alex James, Franca Buelow ... Ann Brower
    There is a systemic bias in research evaluation, i.e., disciplines with a higher proportion of women have lower evaluations and funding success for all researchers, regardless of gender.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Senescent cells inhibit mouse myoblast differentiation via the SASP-lipid 15d-PGJ2 mediated modification and control of HRas

    Swarang Sachin Pundlik, Alok Barik ... Arvind Ramanathan
    Senescent cells release an arachidonic acid-derived electrophilic oxylipin that inhibits myoblast differentiation by covalent modification and activation of HRas.
    Version of Record
    Short Report
    • Useful
    • Incomplete
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination

    Amber R Philp, Carolina R Reyes ... Francisco J Rivera
    Transient platelet accumulation supports oligodendrocyte progenitor cell differentiation during myelin repair, while sustained exposure to elevated platelet numbers hampers the generation of remyelinating cells.
    Version of Record
    Short Report
    • Important
    • Convincing