Browse our Short Reports

Page 55 of 64
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evidence for a common evolutionary rate in metazoan transcriptional networks

    Anne-Ruxandra Carvunis, Tina Wang ... Trey Ideker
    Transcriptional regulation evolves at indistinguishable rates in mammals, birds and insect lineages despite large differences in underlying rates of sequence evolution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome

    Qianglin Fang, Ping Chen ... Rui-Ming Xu
    Distinct binding of viral proteins to the same region on the nucleosome surface can result in contrasting changes to higher-order chromatin structure in the host cell.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe

    Anneke Hibbel, Aliona Bogdanova ... Jonathon Howard
    The budding yeast kinesin Kip2 is a polymerase that uses its processive motility in a positive feedback loop to promote microtubule growth.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Catalysis-dependent selenium incorporation and migration in the nitrogenase active site iron-molybdenum cofactor

    Thomas Spatzal, Kathryn A Perez ... Douglas C Rees
    Unanticipated rearrangements in the nitrogenase active site establish the dynamic nature of the FeMo-cofactor during catalysis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

    David Tse Shen Lin, Elizabeth Conibear
    Palmitate turnover is controlled by distinct enzyme families with different specificities.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression

    Rosa Della Monica, Roberta Visconti ... Domenico Grieco
    The phosphatase Fcp1 inactivates Greatwall kinase at the end of mitosis.
    1. Neuroscience

    Hippocampal ensemble dynamics timestamp events in long-term memory

    Alon Rubin, Nitzan Geva ... Yaniv Ziv
    Temporally close events share a common timestamp regardless of the spatial context in which they occur.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Population genomics reveals the origin and asexual evolution of human infective trypanosomes

    William Weir, Paul Capewell ... Annette MacLeod
    The protozoan parasite Trypanosoma brucei gambiense has undergone recent clonal evolution that reveals the theoretically predicted Meselson effect at a genome-wide level.
    1. Neuroscience

    The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling

    Drew Stenesen, Andrew T Moehlman, Helmut Krämer
    Fly vision depends on a member of the SLC22 transporter family for recycling the histamine neurotransmitter following its uptake by glia and its modification into the transport metabolite carcinine.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Precise assembly of complex beta sheet topologies from de novo designed building blocks

    Indigo Chris King, James Gleixner ... David Baker
    Protein structures with complex topologies can be designed by recombining small independently folded domains.