Browse our Tools and Resources

Page 13 of 83
    1. Developmental Biology

    Molecular characterization of the intact mouse muscle spindle using a multi-omics approach

    Bavat Bornstein, Lia Heinemann-Yerushalmi ... Elazar Zelzer
    Transcriptomic and proteomic analyses of the murine intact muscle spindle provide comprehensive datasets of its different tissues and identify new tools to study its development and function.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

    Yi Fan, Ping Lyu ... Chenchen Zhou
    Single-cell sequencing of the alveolar bone marrow of apical periodontitis reveals the cellular and molecular composition of the microenvironment and highlights an osteogenic potential within mesenchymal stem cells of inflammatory-related bone diseases.
    1. Computational and Systems Biology
    2. Neuroscience

    A hardware system for real-time decoding of in vivo calcium imaging data

    Zhe Chen, Garrett J Blair ... Hugh T Blair
    DeCalciOn is a low-cost open-source hardware system for real-time in vivo calcium imaging that offers capabilities for online decoding of neural population activity and delivery of short latency closed-loop feedback in freely behaving animals.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

    Marina Ainciburu, Teresa Ezponda ... Felipe Prosper
    Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.
    1. Neuroscience

    Histological E-data Registration in rodent Brain Spaces

    Jingyi Guo Fuglstad, Pearl Saldanha ... Jonathan R Whitlock
    HERBS is a catch-all anatomical registration toolkit allowing users to plan surgical coordinates in advance, or visualize anatomical data post hoc in 2D or 3D brain volumes for rats, mice, or any species that has a compatible atlas.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

    Anastasia O Smirnova, Anna M Miroshnichenkova ... Alexander Komkov
    A hallmark property of non-functional clonotypes was used to develop a universal and fully computational method for detection and correction of multiplex PCR-specific quantitative bias in adaptive immune receptor repertoire.
    1. Developmental Biology
    2. Neuroscience

    Transcription factors underlying photoreceptor diversity

    Juan M Angueyra, Vincent P Kunze ... Wei Li
    Tools and resources to identify transcriptional regulators that create and maintain differences between photoreceptor subtypes.
    1. Cell Biology

    A CRISPR screen in intestinal epithelial cells identifies novel factors for polarity and apical transport

    Katharina MC Klee, Michael W Hess ... Lukas A Huber
    Applying a CRISPR knockout screen in polarized intestinal epithelial cells and subsequent phenotypic analyses identified various genes, of which several were previously not associated with epithelial homeostasis, to be relevant for proper epithelial polarization, apical cargo transport, and endo/lysosomal morphology.
    1. Cell Biology

    Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

    Theodore J Zwang, Rachel E Bennett ... Bradley T Hyman
    Conditions for multiplexed antibody labeling in mouse brain tissue translates to effective labeling in human brain tissue when samples are prepared similarly.
    1. Developmental Biology

    A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

    Vincent Loreau, Renate Rees ... Dirk Görlich
    A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.