Browse our Tools and Resources

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    1. Cell Biology

    Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes

    Michelina Kierzek, Parker E Deal ... Christoph Brenker
    FASTM is a novel technique that leverages phase-sensitive signal detection for time-resolved multiplexing of probes with millisecond time resolution, opening new opportunities for interrogating rapid cellular signaling and (bio)chemical reactions.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

    Jugal Mohapatra, Kyuto Tashiro ... Glen Liszczak
    A technology to produce homogenously poly-ADP-ribosylated proteins reveals key molecular mechanisms that govern ATP-dependent chromatin remodeling activity at DNA damage sites.
    1. Neuroscience

    A naturalistic environment to study visual cognition in unrestrained monkeys

    Georgin Jacob, Harish Katti ... SP Arun
    A novel naturalistic environment with a touchscreen enables high-quality eye tracking for studying visual cognition in monkeys, and allows naive monkeys to learn complex tasks through a combination of social observation of trained monkeys and trial-and-error learning.
    1. Cell Biology

    Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism

    Varun Kamat, Brian M Robbings ... Ian R Sweet
    The ability to resolve previously unrecognized affects of O2 and H2S by a novel fluidics system foretell a far-reaching impact of the technology on the study of effects of dissolved gases on tissue function.
    1. Neuroscience

    Standardizing workflows in imaging transcriptomics with the abagen toolbox

    Ross D Markello, Aurina Arnatkeviciute ... Bratislav Misic
    The abagen toolbox provides researchers with tools to systematically process and analyze imaging transcriptomics data, improving standardization of workflows and enabling more comprehensive evaluation of research findings.
    1. Neuroscience

    Double-μPeriscope, a tool for multilayer optical recordings, optogenetic stimulations or both

    Mototaka Suzuki, Jaan Aru, Matthew E Larkum
    Interactions between near but distinct (<1 mm) structures such as cortical layers in the rodent brain can be studied by a new micro-optical tool that is low-cost and capable of multilayer optical recordings, optogenetic stimulations, or both.
    1. Biochemistry and Chemical Biology

    Assessing target engagement using proteome-wide solvent shift assays

    Jonathan G Van Vranken, Jiaming Li ... Steven P Gygi
    Solvent shift assays such as solvent proteome profiling and solvent-PISA are valuable tools for identifying protein-ligand interactions on a proteome-wide scale and can be used to determine drug target engagement, which should benefit future drug discovery efforts.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Framework for rapid comparison of extracellular vesicle isolation methods

    Dmitry Ter-Ovanesyan, Maia Norman ... David R Walt
    Measuring surface proteins on extracellular vesicles enables quantitative comparison of different isolation methods and optimization of size exclusion chromatography.
    1. Neuroscience

    A 3D adult zebrafish brain atlas (AZBA) for the digital age

    Justin W Kenney, Patrick E Steadman ... Paul W Frankland
    A new tool for three-dimensional exploration of adult zebrafish neuroanatomy.
    1. Neuroscience

    The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Cristina Segalin, Jalani Williams ... Ann Kennedy
    The Mouse Action Recognition System is a computational pipeline for automated classification of social behaviors in freely interacting mice, accompanied by a graphical interface for analysis of multimodal neuroscience datasets.