Browse our Tools and Resources

Page 48 of 88
    1. Neuroscience

    Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala

    Timothy P O'Leary, Kaitlin E Sullivan ... Mark S Cembrowski
    Basolateral amygdala excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties.
    1. Structural Biology and Molecular Biophysics

    On the importance of statistics in molecular simulations for thermodynamics, kinetics and simulation box size

    Vytautas Gapsys, Bert L de Groot
    The use of adequate statistics is demonstrated to be an essential prerequisite to derive conclusions on thermodynamics and kinetics from molecular simulations.
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini, Roberta Schulte ... Martin W Hetzer
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
    1. Computational and Systems Biology
    2. Ecology

    Combining agent-based, trait-based and demographic approaches to model coral-community dynamics

    Bruno Sylvain Carturan, Jason Pither ... Lael Parrott
    A new agent-based model enables predicting how coral species richness and functional diversity affect the functioning and resilience of coral reef ecosystems.
    1. Neuroscience

    A flexible framework for simulating and fitting generalized drift-diffusion models

    Maxwell Shinn, Norman H Lam, John D Murray
    Sophisticated decision-making mechanisms and complex experimental paradigms can be modeled, simulated, and fit to empirical response time data, using a flexible and efficient computational modeling framework.
    1. Biochemistry and Chemical Biology

    How to measure and evaluate binding affinities

    Inga Jarmoskaite, Ishraq AlSadhan ... Daniel Herschlag
    Simple guidelines and a checklist are provided for performing high-quality equilibrium binding measurements.
    1. Plant Biology

    Accurate and versatile 3D segmentation of plant tissues at cellular resolution

    Adrian Wolny, Lorenzo Cerrone ... Anna Kreshuk
    Convolutional neural networks and graph partitioning algorithms can be combined into an easy-to-use tool for segmentation of cells in dense plant tissue volumes imaged with light microscopy.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    A community-maintained standard library of population genetic models

    Jeffrey R Adrion, Christopher B Cole ... Andrew D Kern
    The stdpopsim library, a community-driven open source project, is presented which provides easy access to a standard catalog of published simulation models for population genetics aimed at field-wide standardization.
    1. Neuroscience

    A machine-vision approach for automated pain measurement at millisecond timescales

    Jessica M Jones, William Foster ... Ishmail Abdus-Saboor
    Development of a fully automated pain scale using machine learning tools in computational neuroethology and creation of new software, reveals a robust circuit-dissection compatible platform for objective pain measurement.
    1. Neuroscience
    2. Physics of Living Systems

    Revealing architectural order with quantitative label-free imaging and deep learning

    Syuan-Ming Guo, Li-Hao Yeh ... Shalin B Mehta
    Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.