Browse our Tools and Resources

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    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna, Fabrice Uhel ... Molecular Diagnosis and Risk Stratification in Sepsis (MARS) consortium
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling

    Deepti Trivedi, Vinitha CM ... Padinjat Raghu
    A genome editing resource for discovering, in Drosophila, the organization of cellular structure and function by phosphoinositide signaling.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A variant-centric perspective on geographic patterns of human allele frequency variation

    Arjun Biddanda, Daniel P Rice, John Novembre
    New tools for visualizing population genetic data can provide a more direct understanding of levels of differentiation among human populations.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deciphering the combinatorial landscape of immunity

    Antonio Cappuccio, Shane T Jensen ... Elena Zaslavsky
    The immune Synergistic/Antagonistic Interaction Learner (iSAIL) resource has the capacity to generate insight into combinatorial immunity, help guide hypothesis generation and further experimentation relevant to basic research and drug therapeutics.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Massively multiplex single-molecule oligonucleosome footprinting

    Nour J Abdulhay, Colin P McNally ... Vijay Ramani
    A novel single-molecule sequencing method reveals previously unappreciated heterogeneity in nucleosome positioning on individual chromatin fibers across the human genome.
    1. Cell Biology

    Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells

    Lorena Benedetti, Jonathan S Marvin ... Pietro De Camilli
    eMags is an engineered photodimerizer pair for optogenetic modulation in mammalian cells that is especially suited for the manipulation of intracellular processes occurring in small volumes or subcellular organelles.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

    Vivek V Thacker, Neeraj Dhar ... John D McKinney
    Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

    Konstantin Riege, Helene Kretzmer ... Martin Fischer
    A resource of p63-regulated genes, genomic loci bound by p63, p63 DNA recognition motifs, and potential co-factors is generated through a meta-analysis of high-throughput datasets.
    1. Neuroscience

    Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior

    Anton Fomenko, Kai-Hsiang Stanley Chen ... Robert Chen
    Transcranial low-intensity ultrasound applied in block design and at low duty cycles and longer sonication durations can safely and non-invasively suppress human motor-evoked potentials, possibly via GABA-A-mediated inhibitory pathways.
    1. Neuroscience

    An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats

    Thomas Zhihao Luo, Adrian Gopnik Bondy ... Carlos D Brody
    Techniques are presented to facilitate widespread and standardized chronic use of Neuropixels probes for high-yield, long-term neural recording in freely moving animals.