Browse our Tools and Resources

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    1. Genetics and Genomics
    2. Neuroscience

    A scalable platform for the development of cell-type-specific viral drivers

    Sinisa Hrvatin, Christopher P Tzeng ... Michael E Greenberg
    Highly paralleled functional evaluation of enhancer activity in single cells generates new cell-type-specific tools with broad medical and scientific applications.
    1. Neuroscience

    Long-term adult human brain slice cultures as a model system to study human CNS circuitry and disease

    Niklas Schwarz, Betül Uysal ... Henner Koch
    Viral transduction and gene manipulation of adult human brain slices will be of great value allowing investigations including therapeutic screening, electrophysiological and structural studies of properties of human CNS circuitry.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deep generative models for T cell receptor protein sequences

    Kristian Davidsen, Branden J Olson ... Frederick A Matsen IV
    Deep learning improves estimation of T cell receptor cohort frequencies and learns the rules of VDJ recombination, potentially making it helpful for vaccine design.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

    Yuyong Tao, Monika Mis ... Sachdev S Sidhu
    Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.
    1. Neuroscience

    Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice

    Ashley L Juavinett, George Bekheet, Anne K Churchland
    A new device enables researchers to use and recycle extracellular electrodes (e.g. Neuropixels) for high-yield recordings during freely moving mouse experiments.
    1. Neuroscience

    Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T

    Kevin R Sitek, Omer Faruk Gulban ... Federico De Martino
    MRI methods are promising techniques for investigating the human subcortical auditory system, and these publicly available data, atlases, and tools make researching human audition simpler and more reliable.
    1. Cancer Biology

    Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

    Shun Kishimoto, Jeffrey R Brender ... Murali C Krishna
    Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
    1. Neuroscience

    MagC, magnetic collection of ultrathin sections for volumetric correlative light and electron microscopy

    Thomas Templier
    The augmentation of resin-embedded sample blocks with magnetic resin allows remote actuation of ultrathin sections and deposition at high packing density onto silicon wafers for correlative light and electron microscopy.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries

    Michael Luke Carlson, R Greg Stacey ... Franck Duong Van Hoa
    Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.
    1. Cell Biology
    2. Physics of Living Systems

    KymoButler, a deep learning software for automated kymograph analysis

    Maximilian AH Jakobs, Andrea Dimitracopoulos, Kristian Franze
    KymoButler is a machine learning approach towards the reliable, quick, and fully automated analysis of the dynamics of fluorescently labelled particles in living cells.