Kathryn M Tabor, Gregory D Marquart ... Harold A Burgess
A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
Phototrophic growth laws are elucidated by combining computational modeling and experiments for quantitative evaluation of cellular physiology, morphology and proteome allocation across a wide range of light conditions.
A new computational framework provides a flexible and general approach for single and collective biological motion characterisation and phenotyping ideally suited for high-throughput timelapse screens.
Joshua T Vogelstein, Eric W Bridgeford ... Cencheng Shen
Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.
Nicolas P Andrews, Justin X Boeckman ... James S Trimmer
This paper describes an effective pipeline for conversion of conventional monoclonal antibodies into recombinant form that results in an IgG subclass switch that greatly expands their utility for multiplex labeling.
With the removal of confounding artifacts, ribosome profiling can yield insight into the mechanism of protein synthesis in bacteria at high resolution.
Sven Schenk, Stephanie C Bannister ... Kristin Tessmar-Raible
A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.