Browse our Tools and Resources

Page 63 of 88
    1. Neuroscience

    Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping

    Kathryn M Tabor, Gregory D Marquart ... Harold A Burgess
    A new resource of transgenic zebrafish lines facilitates precise targeting of neuronal cell-types within the brain, supported by online software for visualizing transgene expression patterns.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Quantitative insights into the cyanobacterial cell economy

    Tomáš Zavřel, Marjan Faizi ... Jan Červený
    Phototrophic growth laws are elucidated by combining computational modeling and experiments for quantitative evaluation of cellular physiology, morphology and proteome allocation across a wide range of light conditions.
    1. Computational and Systems Biology
    2. Developmental Biology

    Motion sensing superpixels (MOSES) is a systematic computational framework to quantify and discover cellular motion phenotypes

    Felix Y Zhou, Carlos Ruiz-Puig ... Xin Lu
    A new computational framework provides a flexible and general approach for single and collective biological motion characterisation and phenotyping ideally suited for high-throughput timelapse screens.
    1. Computational and Systems Biology
    2. Neuroscience

    Discovering and deciphering relationships across disparate data modalities

    Joshua T Vogelstein, Eric W Bridgeford ... Cencheng Shen
    Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
    1. Biochemistry and Chemical Biology

    Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

    Matthijs Kol, Ben Williams ... James A Frank
    Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
    1. Cell Biology
    2. Developmental Biology

    zGrad is a nanobody-based degron system that inactivates proteins in zebrafish

    Naoya Yamaguchi, Tugba Colak-Champollion, Holger Knaut
    The F-box/anti-GFP nanobody fusion protein zGrad depletes GFP-tagged proteins with spatial and temporal control in zebrafish.
    1. Neuroscience

    A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

    Meng Kuan Lin, Yeonsook Shin Takahashi ... Partha Mitra
    A systematic high-throughput neurohistological and computational pipeline for marmoset which establishes a foundational setup in brain mapping and circuit tracing to support current and emerging research in primate studies.
    1. Neuroscience

    A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain

    Nicolas P Andrews, Justin X Boeckman ... James S Trimmer
    This paper describes an effective pipeline for conversion of conventional monoclonal antibodies into recombinant form that results in an IgG subclass switch that greatly expands their utility for multiplex labeling.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution

    Fuad Mohammad, Rachel Green, Allen R Buskirk
    With the removal of confounding artifacts, ribosome profiling can yield insight into the mechanism of protein synthesis in bacteria at high resolution.
    1. Ecology
    2. Neuroscience

    Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase

    Sven Schenk, Stephanie C Bannister ... Kristin Tessmar-Raible
    A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.