Brian C Del Rosario, Andrea J Kriz ... Jeannie T Lee
The chromosome architectural protein, CTCF, is phosphorylated at Ser224 in a cell-cycle-dependent manner and abrogation of phosphorylation leads to a cell growth defect.
Sujatha Jagannathan, Yuko Ogata ... Robert K Bradley
The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
Maia Azubel, Stephen D Carter ... Roger D Kornberg
Specific attachment of molecularly defined gold nanoparticles enables precise localization, critical for structural studies in vivo, of proteins of unknown structure within the cellular milieu by cryo-electron tomography.
A novel Bayesian method of modeling retinotopic maps is more accurate than traditional voxel-wise methods and can be used to automatically derive high-quality maps.
Maaike Welling, Manuel Alexander Mohr ... Periklis Pantazis
Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.
A method of generating comprehensive maps of cochlear cells was created and enabled researchers to study characteristics of cellular damage in aged and noise-exposed inner ear.
Andrea Giovannucci, Johannes Friedrich ... Eftychios A Pnevmatikakis
CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
Romain F Laine, Gemma Goodfellow ... Clemens F Kaminski
Machine learning in conjunction with super-resolution imaging allows for the first time to quantitatively analyse large and heterogenous virus samples structure at a high throughput and specificity.