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    1. Evolutionary Biology
    2. Genetics and Genomics

    The primate Major Histocompatibility Complex as a case study of gene family evolution

    Alyssa Lyn Fortier, Jonathan K Pritchard
    The Major Histocompatibility Complex region evolves via gene birth-and-death, resulting in short-lived genes, rapidly expanding gene subfamilies, and many gene fragments.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets

    Benjamin Gallean, Tao Laurent ... Emmanuel Faure
    A collaborative open-source platform enabling interactive 3D visualization, quantitative evaluation, and expert curation of complex biological morphologies to enhance the quality and reproducibility of large-scale imaging studies.
    1. Developmental Biology

    Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Eed, a core subunit of Polycomb repressive complex 2, is required for craniofacial osteoblast differentiation and mesenchymal proliferation after induction of the neural crest.
    1. Neuroscience

    Distinct brain mechanisms support trust violations, belief integration, and bias in human-AI teams

    Luisa Roeder, Pamela Hoyte ... Johan N van der Meer
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    Pre-Cambrian origin of envelope-carrying retrotransposons in metazoans

    Shashank Chary, Rippei Hayashi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Cross-species standardised cortico-subcortical tractography

    Stephania Assimopoulos, Shaun Warrington ... Stamatios N Sotiropoulos
    By providing new ways to map cortico-subcortical connectivity patterns, the proposed cross-species tractography approaches directly allow novel comparative studies between the human and macaque brain and enable subsequent explorations of brain-behaviour/disease symptom associations across individuals.
    1. Neuroscience

    C. elegans food choice exhibits effort discounting-like behavior

    Jonathan RM Millet, Serge Faumont ... Shawn R Lockery
    The demonstration of effort discounting-like behavior in a lower invertebrate sets a new phylogenetic boundary on discounting behavior.
    1. Epidemiology and Global Health

    Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis

    Pablo Ruiz Cuenca, Fábio N Souza ... Emanuele Giorgi
    Step selection functions are a useful tool for analysing fine-scale human movements to understand environmental interactions in the context of infectious disease epidemiology.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Joint profiling of cell morphology and gene expression during in vitro neurodevelopment

    Adithi Sundaresh, Dimitri Meistermann ... Helena Kilpinen
    Molecular and morphological profiles of developing neurons in vitro uncover the cellular dynamics of human neurodevelopment and related disease.
    1. Cell Biology

    Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    In vitro reconstitution identifies how lysosome-related vacuoles coordinate the synthesis and turnover of inorganic polyphosphates to create a powerful buffer system stabilising a vital metabolic parameter, the cytosolic concentration of phosphate.