Mayalen Etcheverry, Clément Moulin-Frier ... Michael Levin
A novel methodology, using diversity search AI algorithms, for exploring the space of possible behaviors of gene regulatory networks, from the perspective of generic problem-solving agents navigating their environment.
Claire Meissner-Bernard, Friedemann Zenke, Rainer W Friedrich
Computational modeling revealed that balanced assemblies of excitatory and inhibitory neurons shape representational manifolds in olfactory cortex-like recurrent networks, resulting in joint maps of sensory and semantic information.
Significant technical improvement in single-nucleus RNA-seq reveals distinct adipocyte subpopulations that respond differently to obesity, including those undergoing adaptive healthy expansion and others displaying severe dysfunction.
Cristina Gil Avila, Elisabeth S May ... Markus Ploner
Multiverse analysis of the aperiodic component of the electroencephalography (EEG) power spectrum yielded robust evidence against a relationship to chronic pain, guiding further research on EEG biomarkers of chronic pain.
An eco-evolutionary model shows that heterozygote advantage can maintain over 100 major histocompatibility complex alleles, providing a potent explanation for extraordinary immune gene diversity and challenges previous models that predicted limited allele coexistence.
Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
