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Analysis of phenotype and molecular pathogenesis in a new LAMA2-related muscular dystrophy mouse model.

Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.

Sex-biased gene expression in the body organs evolves rapidly, supporting a mosaic model of maleness and femaleness across tissues and thus challenging binary views of sex characteristics in mammals.

A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.

Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.

Deleting SfPat prophage reduces Shewanella fidelis motility, increases biofilms, changes pdeB expression and spatial retention in Ciona gut, while Ciona VCBP-C binding to the WT strain results in reduced expression of viral capsid proteins without inducing SOS, indicating tripartite interactions.

Diverse magnetotactic bacteria are adapted to the local geomagnetic field and grain size to maximize their swimming speed through the pore space.

Fully autonomous home-cage training system HABITS enables mice to learn complex cognitive behaviors without human intervention, expanding behavioral paradigms and optimizing training efficiency through machine teaching algorithms.

KIF7 loss of function affects several developmental stages of the cerebral cortex and likely causes neurodevelopmental delay, intellectual disability, and epilepsia observed in ciliopathic patients with KIF7 mutations.