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Page 158 of 1,773
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

    Jie Luo, Jeff Ranish
    A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.
    1. Neuroscience

    Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses

    Irene Martínez-Gallego, Heriberto Coatl-Cuaya, Antonio Rodriguez-Moreno
    Two different forms of brain plasticity require astrocytes and show different action mechanisms at enthorrinal cortex hippocampal synapses.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks

    Gaetan De Waele, Gerben Menschaert, Willem Waegeman
    It is possible to accurately recommend antimicrobial drugs from mass spectra using neural networks and large datasets, paving the way for more efficient clinical diagnostics.
    1. Structural Biology and Molecular Biophysics

    Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

    Yuanyuan Wang, Fan Xu ... Yongning He
    The binding site and potential mechanism of human SCARF1 for lipoprotein recognition are identified by combining the crystal structural determination of the N-terminal fragments and biochemical and cellular assays.
    1. Microbiology and Infectious Disease

    Membrane binding properties of the cytoskeletal protein bactofilin

    Ying Liu, Rajani Karmakar ... Martin Thanbichler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Evolutionary Biology

    Biases of Principal Component Analysis (PCA) in Physical Anthropology Studies Require a Reevaluation of Evolutionary Insights

    Nima Mohseni, Eran Elhaik
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice

    Puqiao Lian, Artemiy Kovynev ... Saskia Braber
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Medicine
    2. Neuroscience

    Hemispheric divergence of interoceptive processing across psychiatric disorders

    Emily M Adamic, Adam R Teed ... Sahib Khalsa
    Asymmetric activation of the dysgranular mid-insula during interoceptive processing contributes to disrupted bodily awareness in individuals with anxiety, depression, and eating disorders.
    1. Neuroscience

    CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction

    Natalia Mendes, Ariane Zanesco ... Licio A Velloso
    A subset of myeloid cells expressing CXCR3 is recruited to the hypothalamus and protects against the metabolic abnormalities generated in diet-induced obesity.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Functional characteristics and computational model of abundant hyperactive loci in the human genome

    Sanjarbek Hudaiberdiev, Ivan Ovcharenko
    Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.
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