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    1. Neuroscience

    Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex

    Guanhua Sun, James Hazelden ... Daniel B Forger
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology

    Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

    Ravindra B Chalamalasetty, Haley Tran ... Terry P Yamaguchi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A tool to pulse-label yeast Nuclear Pore Complexes in imaging and biochemical experiments

    Annemiek C Veldsink, Jonas S Fischer ... Liesbeth M Veenhoff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Prenatal light exposure affects number sense and the mental number line in young domestic chicks

    Rosa Rugani, Matteo Macchinizzi ... Lucia Regolin
    In ovo light exposure that induces brain lateralization boosts chicks' number sense and spatial-numerical association.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity

    A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind
    A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
    1. Evolutionary Biology

    Genetic parallels in biomineralization of the calcareous sponge Sycon ciliatum and stony corals

    Oliver Voigt, Magdalena V Wilde ... Gert Wörheide
    Discovery of calcarins in calcareous sponges highlights gene duplication and neofunctionalization as drivers of parallel biomineralization, offering insight into the independent evolution of calcification in early-diverging animals.
    1. Immunology and Inflammation
    2. Neuroscience

    Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress

    Alina Malita, Anne H Skakkebaek ... Kim Rewitz
    Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative sleep behaviors essential for mental well-being.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline

    Rui Feng, Sarah F Rosen ... Valeria Cavalli
    Inhibition of the endothelin B receptor (ETBR) with FDA-approved Bosentan enhances axon regeneration and reverses age-related decline, revealing a promising therapeutic target for improving nerve repair in older individuals.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development

    Pramila Rijal, Leiyan Wei ... Alain RM Townsend
    Grafting surface loops containing antibody epitopes of a poorly expressed flu neuraminidase protein onto a high-expressing, stable scaffold improves its production and stability for vaccine development.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes

    Gautham Ganesh, Jean-Bernard Fiche ... Julien Mozziconacci
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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