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Page 186 of 1,773
    1. Evolutionary Biology

    Evolution of novel mimicry polymorphisms through Haldane’s sieve and rare recombination

    Riddhi Deshmukh, Saurav Baral ... Krushnamegh Kunte
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Benchmarking tRNA-Seq quantification approaches by realistic tRNA-Seq data simulation identifies two novel approaches with higher accuracy

    Tom Smith, Mie Monti ... Lajos Kalmár
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

    Yan Chen, Ruizhi Yang ... Zhao Shan
    Chi3l1 binds to bacterial peptidoglycan, helping anchor and organize bacteria within the mucus layer.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamic basis of lipopolysaccharide export by LptB2FGC

    Marina Dajka, Tobias Rath ... Benesh Joseph
    LptC regulates the LPS entry gate in LptB2FG, likely through a dynamic behavior of its transmembrane helix, while the β-jellyroll domains are tethered in the periplasm.
    1. Biochemistry and Chemical Biology

    Single turnover transient state kinetics reveals processive protein unfolding catalyzed by Escherichia coli ClpB

    Jaskamaljot Kaur Banwait, Liana Islam, Aaron L Lucius
    Development of sequential mixing, single turnover stopped-flow approach reveals processive protein unfolding catalyzed by Escherichia coli ClpB.
    1. Computational and Systems Biology
    2. Neuroscience

    Robust, fast and accurate mapping of diffusional mean kurtosis

    Megan E Farquhar, Qianqian Yang, Viktor Vegh
    Mean kurtosis brain maps, derived from a sub-diffusion model with a novel clinically feasible two-diffusion-time acquisition, exhibit superior tissue contrast compared to the traditional diffusional kurtosis imaging (DKI).
    1. Structural Biology and Molecular Biophysics

    Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

    Shristi Pawnikar, Brenda S Magenheimer ... Yinglong Miao
    Structural dynamic insights revealed the mechanisms of PC1 activation by stalk-derived peptide agonists which can form a foundation for development of PC1 as a therapeutic target for ADPKD treatment.
    1. Cancer Biology

    BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

    Paul Huchede, Swann Meyer ... Marie Castets
    BMP2 and 7 synergize with H3.3K27M epigenetic context to establish a quiescent but invasive state in pediatric diffuse midline gliomas.
    1. Microbiology and Infectious Disease

    Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3

    Nicholas J Hathaway, Isaac E Kim ... Jeffrey A Bailey
    Sequence analyses show a pfhrp3 deletion mechanism involves duplication of chromosome 11 segment, which is normally removed via negative selection, and specific conditions are needed for spread including low transmission.
    1. Cancer Biology

    Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer

    Xujin Wei, Jie Liu ... Huiqin Zhuo
    CUT-Tag is used to identify super-enhancers (SEs) for the first time in gastric cancer, and the mRNA decay mechanism activated by SE-driven ZFP36L1 in infiltrative gastric cancer along with innovative experimental evidence demonstrating SPI1/ZFP36L1/HDAC3/PD-L1 signaling axis are presented.
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