Browse the latest research

Page 20 of 1,779
    1. Neuroscience

    A toolbox for ablating excitatory and inhibitory synapses

    Aida Bareghamyan, Changfeng Deng ... Don B Arnold
    Novel genetically encoded tools PFE3, paGFE3, and chGFE3 can be used to reversibly ablate excitatory synapses constitutively, and inhibitory synapses in a light- or chemically dependent manner.
    1. Ecology

    A circadian clock drives behavioral activity in Antarctic krill (Euphausia superba) and provides a potential mechanism for seasonal timing

    Lukas Hüppe, Dominik Bahlburg ... Bettina Meyer
    Behavioral experiments provide strong evidence that krill swimming behavior is controlled by biological clocks throughout the year, revealing a key mechanism for adaptation to high-latitude habitats.
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

    Jeremy M Shea, Saul A Villeda
    During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.
    1. Neuroscience

    Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

    Patricia E Phelps, Sung Min Ha ... Xia Yang
    To better understand how olfactory ensheathing cells modify spinal cord injury sites, single-cell RNA-sequencing was used to identify five OEC subtypes, progenitors, and novel genes associated with axonal outgrowth.
    1. Neuroscience

    Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

    William Hockeimer, Ruo-Yah Lai ... James J Knierim
    Place cells that show repeating place fields in geometrically similar locations of an environment modulate their firing rates differently in each field based on movement direction.
    1. Microbiology and Infectious Disease

    Secretory leukocyte protease inhibitor influences periarticular joint inflammation in B. burgdorferi-infected mice

    Qian Yu, Xiaotian Tang ... Erol Fikrig
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia

    Nguyet Le, Sherine Awad ... Seth Blackshaw
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Developmental Biology

    The epididymis contributes to sperm DNA integrity and early embryo development through Cysteine-Rich Secretory Proteins

    Valeria Sulzyk, Ludmila Curci ... Patricia S Cuasnicu
    The identification of epididymal proteins relevant for sperm DNA integrity and early embryo development will contribute to a better understanding, diagnosis, and treatment of human infertility.
    1. Neuroscience

    Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances

    Zachary Fournier, Leandro M Alonso, Eve Marder
    Modifications of the intrinsic currents in neuronal circuits are more likely to result in loss of function than changes in synaptic strength.