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    1. Developmental Biology
    2. Neuroscience

    Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord

    Bridget M Curran, Kelsey R Nickerson ... Le Ma
    Formation of dorsal axonal tracts in the spinal cord depends on multiple guidance mechanisms that control growth direction of bifurcating axons in the dorsal root entry zone.
    1. Immunology and Inflammation

    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

    Chan-Su Park, Jian Guan ... Scheherazade Sadegh-Nasseri
    Fam49b is a critical regulator of selection process to ensure normal thymocyte development and peripheral T cells survival.
    1. Evolutionary Biology

    Beyond Haldane’s rule: Sex-biased hybrid dysfunction for all modes of sex determination

    Asher D Cutter
    A broad and inclusive view of sex biases in hybrid dysfunction, irrespective of sexual system, expands the reach of Haldane's rule to help characterize the underlying forces and mechanisms responsible for predictable sex biases in evolutionary divergence and speciation.
    1. Structural Biology and Molecular Biophysics

    Decoupling of the onset of anharmonicity between a protein and its surface water around 200 K

    Lirong Zheng, Bingxin Zhou ... Liang Hong
    The dynamical transition between a protein and its surface water is decoupled.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Neuroscience

    A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus

    Noémie Reveyaz, Undine Schneeweiß ... Michael Brecht
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation

    IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

    Yaping Chen, Pengcheng Zhou ... Di Yu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality

    Qiong He, Miao-Miao Zhao ... Jin-Kui Yang
    High glucose levels promote CTSL maturation and translocation from the endoplasmic reticulum to the lysosome via the ER-Golgi-lysosome axis.
    1. Evolutionary Biology

    Biocalcification in porcelaneous foraminifera

    Zofia Dubicka, Jarosław Tyszka ... Ulf Bickmeyer
    Porcelaneous foraminifera, marine calcifiers, reveal their biomineralization secrets.
    1. Neuroscience

    Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

    Ethan H Willbrand, Yi-Heng Tsai ... Kevin S Weiner
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cancer Biology

    Exploring the role of the immune microenvironment in hepatocellular carcinoma: Implications for immunotherapy and drug resistance

    Yumin Fu, Xinyu Guo ... Lianxin Liu
    The immune microenvironment has a pivotal role in hepatocellular carcinoma (HCC) progression and immune therapy resistance, and targeting this complex milieu holds great promise for improving therapeutic outcomes and patient prognoses in HCC management.
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