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Single-nuclear transcriptomic profiling and functional assays identified PKR activation and mitochondrial dysfunction in HIV-associated nephropathy mice kidneys.

Mouse TRIP13 localizes to synapsed chromosomal axes and thus exhibits mutually exclusive localization with HORMAD1/HORMAD2, providing a cell biological explanation for dissociation of HORMAD1/2 from chromosomal axes upon synapsis.

CysM and CysK2 play complementary and overlapping roles in Mtb's adaptation to environmental stress that are crucial for survival.

Chronic bacteriophages are induced by the supplement of polysaccharide in the deep-sea Lentisphaerae strains, and these bacteriophages potentially reprogram host polysaccharide metabolism through the auxiliary metabolic genes.

Isotonic treatment limits keratinocyte movement, spatially restricts reactive oxygen species production, and rescues sensory neuron function after thermal injury.

Preoptic neurotensinergic neurons co-release GABA and neurotensin, triggering a rapid initial inhibition followed by a sustained excitation, and mice lacking GABA release from these neurons exhibit altered thermoregulation.

Proteins that are low abundant and/or poorly accessible to antibodies can be readily localised with fluorescent streptavidin, when expressed fused to a biotin ligase.

A biophysical approach sheds light on the electron transport physics and electric metabolism of centimeter-long filamentous freshwater cable bacteria.

Low-dimensional external inputs are sufficient to control the speed of sequential activity, and to transition between persistent activity, in a network of neurons with both temporally symmetric and asymmetric learning.

First high-resolution structure of HGSNAT-acetyl-CoA complex, that describes the architecture of a novel transmembrane N-acetyltransferase fold and provides a molecular basis for MPS IIIC causing mutation induced destabilization of HGSNAT.