BoNT intoxication of neurons is revisited using a genome-wide siRNA screen and organelle-specific reporters, suggesting a mechanism of translocation to the cytosol fundamentally different than previously proposed.
Sofie Louise Valk, Veronika Engert ... Tania Singer
Socio-emotional behavioral intervention links to changes in the structure and function of hippocampal subfields, in particular CA1-3, and reductions in cortisol levels in healthy adults.
Anastasia D Komarova, Snezhana D Sinyushkina ... Marina V Shirmanova
The level of heterogeneity of cellular energy metabolism increases with model complexity and is the highest in patients' tumors, which can be observed and quantified using FLIM of NAD(P)H.
The common ancestor of extant mammalian coronaviruses originated recently in a bat species and their diversification occurred via preferential host switches rather than through codiversification with mammals.
Senescent cells release an arachidonic acid-derived electrophilic oxylipin that inhibits myoblast differentiation by covalent modification and activation of HRas.
The amyloid polymorph selection that occurs during α-synuclein aggregation is dictated by environmental conditions, in particular pH, with the largest variety of structures being observed near neutral pH.
Connectomic, optogenetic, and high-throughput behavioral analyses identify a descending neuron in the fruit fly larval brain that modifies the timing of nociception-induced rolling.
